Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism.

Animals Cell Line Cell Proliferation Cholesterol / metabolism Gene Expression Regulation Golgi Apparatus / metabolism Humans Hyperlipidemias / genetics Lipid Metabolism / genetics Membrane Proteins / metabolism Proprotein Convertases / metabolism Serine Endopeptidases / metabolism Sterol Regulatory Element Binding Proteins / metabolism Zebrafish

Journal

Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592

Informations de publication

Date de publication:
06 2020
Historique:
received: 02 12 2019
accepted: 15 04 2020
entrez: 23 7 2020
pubmed: 23 7 2020
medline: 1 1 2021
Statut: ppublish

Résumé

Coessentiality mapping has been useful to systematically cluster genes into biological pathways and identify gene functions

Identifiants

DOI: 10.1038/s42255-020-0206-9 PMID: 32694732 PMC: PMC7384252
pubmed: 32694732
doi: 10.1038/s42255-020-0206-9
pii: 10.1038/s42255-020-0206-9
pmc: PMC7384252
mid: NIHMS1584997
doi:

Substances chimiques

Membrane Proteins 0
SPRING1 protein, human 0
Sterol Regulatory Element Binding Proteins 0
Cholesterol 97C5T2UQ7J
Proprotein Convertases EC 3.4.21.-
Serine Endopeptidases EC 3.4.21.-
membrane-bound transcription factor peptidase, site 1 EC 3.4.21.112

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

487-498

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM117473
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK123323
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM135926
Pays : United States
Organisme : NIDCR NIH HHS
ID : F31 DE030007
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113362
Pays : United States
Organisme : NHGRI NIH HHS
ID : R35 HG010718
Pays : United States

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Auteurs

Erol C Bayraktar (EC)

Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.

Konnor La (K)

Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.

Kara Karpman (K)

Center for Applied Mathematics, Cornell University, Ithaca, NY, USA.

Gokhan Unlu (G)

Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
ORCID: 0000-0002-2704-2724

Ceren Ozerdem (C)

Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0001-6772-0422

Dylan J Ritter (DJ)

Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
ORCID: 0000-0002-8704-908X

Hanan Alwaseem (H)

Proteomics Resource Center, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0002-4946-1436

Henrik Molina (H)

Proteomics Resource Center, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0001-8950-4990

Hans-Heinrich Hoffmann (HH)

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.

Alec Millner (A)

Department of Chemistry, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA.

G Ekin Atilla-Gokcumen (GE)

Department of Chemistry, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA.

Eric R Gamazon (ER)

Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0003-4204-8734

Amy R Rushing (AR)

Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Ela W Knapik (EW)

Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
ORCID: 0000-0002-2977-3619

Sumanta Basu (S)

Department of Statistics and Data Science, Cornell University, Ithaca, NY, USA.

Kıvanç Birsoy (K)

Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA. kbirsoy@rockefeller.edu.
ORCID: 0000-0002-7579-9895

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Appareil de Golgi › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme lipidique › Dyslipidémies › Hyperlipidémies › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Proprotein convertases › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › Protéines de liaison à l'élément de régulation des stérols › Metabolic coessentiality mapping identifies...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Metabolic coessentiality mapping identifies...