A Novel Cecropin-LL37 Hybrid Peptide Protects Mice Against EHEC Infection-Mediated Changes in Gut Microbiota, Intestinal Inflammation, and Impairment of Mucosal Barrier Functions.

Animals Antimicrobial Cationic Peptides / pharmacology Cecropins / pharmacology Escherichia coli Infections / pathology Escherichia coli O157 Female Gastrointestinal Microbiome / drug effects Inflammation / microbiology Intestinal Diseases / microbiology Intestinal Mucosa / drug effects Mice Mice, Inbred C57BL Recombinant Proteins / pharmacology Cathelicidins
Escherichia coli O157:H7 enrofloxacin hybrid peptide inflammation microflora mucosal barrier

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 18 11 2019
accepted: 28 05 2020
entrez: 23 7 2020
pubmed: 23 7 2020
medline: 7 4 2021
Statut: epublish

Résumé

Intestinal inflammation can cause impaired epithelial barrier function and disrupt immune homeostasis, which increases the risks of developing many highly fatal diseases. Enterohemorrhagic

Identifiants

DOI: 10.3389/fimmu.2020.01361 PMID: 32695115 PMC: PMC7338479
pubmed: 32695115
doi: 10.3389/fimmu.2020.01361
pmc: PMC7338479
doi:

Substances chimiques

Antimicrobial Cationic Peptides 0
Cecropins 0
Recombinant Proteins 0
Cathelicidins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1361

Informations de copyright

Copyright © 2020 Wei, Zhang, Zhang, Koci, Si, Ahmad, Cheng, Wang, Aihemaiti and Zhang.

Références

Infect Immun. 2008 Apr;76(4):1340-8
pubmed: 18227169
Mucosal Immunol. 2010 Mar;3(2):100-3
pubmed: 20016473
Peptides. 2008 Nov;29(11):2001-12
pubmed: 18708104
Gut. 2014 May;63(5):711-9
pubmed: 23676441
Gut. 2015 Nov;64(11):1732-43
pubmed: 25614621
Nature. 2015 Jan 15;517(7534):311-20
pubmed: 25592536
Nat Rev Microbiol. 2019 Aug;17(8):497-511
pubmed: 31249397
J Pediatr Gastroenterol Nutr. 2010 Mar;50(3):321-8
pubmed: 20118807
Sci Transl Med. 2018 Dec 19;10(472):
pubmed: 30567928
J Clin Microbiol. 2006 Nov;44(11):3980-8
pubmed: 16988018
Br J Pharmacol. 2013 Nov;170(5):1078-91
pubmed: 23941302
Nat Clin Pract Gastroenterol Hepatol. 2006 Jul;3(7):390-407
pubmed: 16819502
Arch Surg. 1970 Oct;101(4):484-8
pubmed: 5311679
Surg Oncol. 2017 Dec;26(4):368-376
pubmed: 29113654
Therap Adv Gastroenterol. 2016 Jul;9(4):606-25
pubmed: 27366227
Int J Colorectal Dis. 2009 Jan;24(1):5-12
pubmed: 18685855
Nat Rev Drug Discov. 2013 May;12(5):371-87
pubmed: 23629505
Am J Gastroenterol. 2007 Sep;102(9):2058-69
pubmed: 17561966
Dig Dis Sci. 2001 Oct;46(10):2222-30
pubmed: 11680601
Dis Model Mech. 2018 Nov 16;11(11):
pubmed: 30275104
Nature. 2008 Jul 24;454(7203):428-35
pubmed: 18650913
J Immunol. 2015 Feb 15;194(4):1882-93
pubmed: 25601921
Int J Mol Sci. 2019 Aug 15;20(16):
pubmed: 31443263
Dig Liver Dis. 2005 Nov;37(11):838-49
pubmed: 16169298
Scand J Gastroenterol. 2011 Jun;46(6):684-93
pubmed: 21410316
Invest Ophthalmol Vis Sci. 2016 Jan 1;57(1):30-9
pubmed: 26746016
Dig Dis Sci. 1994 Dec;39(12):2575-88
pubmed: 7995182
Vet Res Commun. 2015 Mar;39(1):53-60
pubmed: 25686865
J Nutr. 2016 May;146(5):964-9
pubmed: 27029941
J Nutr Biochem. 2018 Nov;61:111-128
pubmed: 30196243
Lancet. 2005 Mar 19-25;365(9464):1073-86
pubmed: 15781103
Braz J Med Biol Res. 2015 Feb;48(2):96-107
pubmed: 25466162
Int J Mol Sci. 2018 Dec 12;19(12):
pubmed: 30545135
Nat Rev Genet. 2014 Jun;15(6):362
pubmed: 24759330
Int Immunopharmacol. 2018 May;58:64-71
pubmed: 29555328
J Nutr Biochem. 2015 Oct;26(10):1050-7
pubmed: 26070414
Annu Rev Biochem. 2002;71:635-700
pubmed: 12045108
BMC Gastroenterol. 2014 Feb 13;14:29
pubmed: 24524552
Gut. 2010 Apr;59(4):452-60
pubmed: 19996326
J Nutr Biochem. 2012 May;23(5):430-6
pubmed: 21658926
Antimicrob Agents Chemother. 2013 Mar;57(3):1480-7
pubmed: 23318793
Arch Insect Biochem Physiol. 2015 Jan;88(1):31-44
pubmed: 25319409
Gastroenterology. 2008 Feb;134(2):577-94
pubmed: 18242222
Dig Dis. 2009;27(4):450-4
pubmed: 19897959
Sci Rep. 2019 Jul 1;9(1):9456
pubmed: 31263234
Gastroenterology. 2017 Feb;152(2):327-339.e4
pubmed: 27769810
Int J Mol Sci. 2016 Jun 29;17(7):
pubmed: 27367675
Genome Biol Evol. 2014 Mar;6(3):703-13
pubmed: 24625961
Nat Med. 2019 Feb;25(2):323-336
pubmed: 30664783
World J Gastroenterol. 2018 Jan 7;24(1):5-14
pubmed: 29358877
Front Immunol. 2019 Jun 14;10:1365
pubmed: 31258535
Inflamm Res. 2002 Apr;51(4):201-5
pubmed: 12058958
BMC Vet Res. 2013 Jun 25;9:126
pubmed: 23800340
Drug Chem Toxicol. 2017 Jul;40(3):295-299
pubmed: 28122461
Am J Gastroenterol. 2014 Feb;109(2):279-87
pubmed: 24322838
Immunity. 1999 Jul;11(1):115-22
pubmed: 10435584
Mediators Inflamm. 2015;2015:167572
pubmed: 26612970
Nat Med. 2000 May;6(5):583-8
pubmed: 10802717
Front Immunol. 2019 Aug 06;10:1841
pubmed: 31447849
Turk J Gastroenterol. 2014 Dec;25(6):603-10
pubmed: 25599768

Auteurs

Xubiao Wei (X)

Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Lulu Zhang (L)

Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Rijun Zhang (R)

Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Matthew Koci (M)

Prestage Department of Poultry Science, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC, United States.

Dayong Si (D)

Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Baseer Ahmad (B)

Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Junhao Cheng (J)

Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Junyong Wang (J)

Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Maierhaba Aihemaiti (M)

Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Manyi Zhang (M)

Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A Novel Cecropin-LL37 Hybrid Peptide Protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › A Novel Cecropin-LL37 Hybrid Peptide Protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Cécropines › A Novel Cecropin-LL37 Hybrid Peptide Protects...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Infections à Escherichia coli › A Novel Cecropin-LL37 Hybrid Peptide Protects...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Escherichia coli producteur de Shiga-toxine › Escherichia coli entérohémorrhagique › Escherichia coli O157 › A Novel Cecropin-LL37 Hybrid Peptide Protects...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › A Novel Cecropin-LL37 Hybrid Peptide Protects...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › A Novel Cecropin-LL37 Hybrid Peptide Protects...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › A Novel Cecropin-LL37 Hybrid Peptide Protects...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › A Novel Cecropin-LL37 Hybrid Peptide Protects...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A Novel Cecropin-LL37 Hybrid Peptide Protects...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › A Novel Cecropin-LL37 Hybrid Peptide Protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › A Novel Cecropin-LL37 Hybrid Peptide Protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Cathélicidines › A Novel Cecropin-LL37 Hybrid Peptide Protects...