Inhibition of Oxidative Phosphorylation Reverses Bone Marrow Hypoxia Visualized in Imageable Syngeneic B-ALL Mouse Model.
acute lymphobastic leukemia
bone marrow
hypoxia
leukemia
oxidative phosphorylation
oxygen
vascularity
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
02
2020
accepted:
19
05
2020
entrez:
23
7
2020
pubmed:
23
7
2020
medline:
23
7
2020
Statut:
epublish
Résumé
Abnormally low level of interstitial oxygen, or hypoxia, is a hallmark of tumor microenvironment and a known promoter of cancer chemoresistance. Inside a solid tumor mass, the hypoxia stems largely from inadequate supply of oxygenated blood through sparse or misshapen tumor vasculature whilst oxygen utilization rates are low in typical tumor's glycolytic metabolism. In acute leukemias, however, markers of intracellular hypoxia such as increased pimonidazole adduct staining and HIF-1α stabilization are observed in advanced leukemic bone marrows (BM) despite an increase in BM vasculogenesis. We utilized intravital fast scanning two-photon phosphorescence lifetime imaging microscopy (FaST-PLIM) in a BCR-ABL B-ALL mouse model to image the extracellular oxygen concentrations (pO
Identifiants
pubmed: 32695673
doi: 10.3389/fonc.2020.00991
pmc: PMC7339962
doi:
Types de publication
Journal Article
Langues
eng
Pagination
991Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB018464
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA231364
Pays : United States
Organisme : NINDS NIH HHS
ID : R24 NS092986
Pays : United States
Organisme : NHLBI NIH HHS
ID : K25 HL145092
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA155056
Pays : United States
Informations de copyright
Copyright © 2020 Rytelewski, Harutyunyan, Baran, Mallampati, Zal, Cavazos, Butler, Konoplev, El Khatib, Plunkett, Marszalek, Andreeff, Zal and Konopleva.
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