Exploring the Histone Acetylation Cycle in the Protozoan Model
Tetrahymena
bromodomain
chromatin remodeling
histone acetyltransferase
histone deacetylase Tetrahymena thermophila
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
04
2020
accepted:
28
05
2020
entrez:
23
7
2020
pubmed:
23
7
2020
medline:
23
7
2020
Statut:
epublish
Résumé
The eukaryotic histone acetylation cycle is composed of three classes of proteins, histone acetyltransferases (HATs) that add acetyl groups to lysine amino acids, bromodomain (BRD) containing proteins that are one of the most characterized of several protein domains that recognize acetyl-lysine (Kac) and effect downstream function, and histone deacetylases (HDACs) that catalyze the reverse reaction. Dysfunction of selected proteins of these three classes is associated with human disease such as cancer. Additionally, the HATs, BRDs, and HDACs of fungi and parasitic protozoa present potential drug targets. Despite their importance, the function and mechanisms of HATs, BRDs, and HDACs and how they relate to chromatin remodeling (CR) remain incompletely understood.
Identifiants
pubmed: 32695779
doi: 10.3389/fcell.2020.00509
pmc: PMC7339932
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
509Informations de copyright
Copyright © 2020 Wahab, Saettone, Nabeel-Shah, Dannah and Fillingham.
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