Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia.
Airway Remodeling
/ drug effects
Animals
Animals, Newborn
Bronchopulmonary Dysplasia
/ chemically induced
Disease Models, Animal
Hyperoxia
/ chemically induced
Lung
/ drug effects
Methanol
/ analogs & derivatives
Mice, Knockout
Phosphotransferases (Alcohol Group Acceptor)
/ drug effects
Pyrrolidines
/ pharmacology
Reactive Oxygen Species
/ metabolism
Signal Transduction
/ drug effects
Sulfones
PF543
airway remodeling
bronchopulmonary dysplasia
mitochondrial ROS
sphingosine kinase 1
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
pubmed:
23
7
2020
medline:
1
12
2020
entrez:
23
7
2020
Statut:
ppublish
Résumé
Hyperoxia (HO)-induced lung injury contributes to bronchopulmonary dysplasia (BPD) in preterm newborns. Intractable wheezing seen in BPD survivors is associated with airway remodeling (AWRM). Sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) signaling promotes HO-mediated neonatal BPD; however, its role in the sequela of AWRM is not known. We noted an increased concentration of S1P in tracheal aspirates of neonatal infants with severe BPD, and earlier, demonstrated that
Identifiants
pubmed: 32697651
doi: 10.1152/ajplung.00169.2020
pmc: PMC7518054
doi:
Substances chimiques
PF-543
0
Pyrrolidines
0
Reactive Oxygen Species
0
Sulfones
0
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
Sphk1 protein, mouse
EC 2.7.1.-
Methanol
Y4S76JWI15
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
L497-L512Subventions
Organisme : NICHD NIH HHS
ID : R01 HD090887
Pays : United States
Organisme : HHS | NIH | National Institute of Child Health and Human Development (NICHD)
ID : R01HD090887-01A1
Pays : International
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