In vitro antioxidant and antityrosinase activities of Manilkara kauki.
Manilkara kauki
antioxidant
total flavonoid content
total phenolic content
tyrosinase inhibitor
Journal
Acta pharmaceutica (Zagreb, Croatia)
ISSN: 1846-9558
Titre abrégé: Acta Pharm
Pays: Poland
ID NLM: 9303678
Informations de publication
Date de publication:
01 Mar 2021
01 Mar 2021
Historique:
accepted:
03
04
2020
entrez:
23
7
2020
pubmed:
23
7
2020
medline:
1
5
2021
Statut:
ppublish
Résumé
Manilkara kauki L. Dubard is a tropical plant in the genus Manilkara of family Sapotaceae. This study investigated the total phenolic and flavonoid contents, and antioxidant and antityrosinase activities in different parts of M. kauki (fruits, leaves, seeds, stem barks and woods) and in fractions of stem barks. The total phenolic and flavonoid contents of the methanol and aqueous crude extracts of different parts of M. kauki ranged from 10.87 to 176.56 mg GAE (gallic acid equivalents) per gram of crude extract and 14.33 to 821.67 mg QE (quercetin equivalents) per gram of crude extract, resp. Leaves and stem barks exhibited higher total phenolic and flavonoid contents and antioxidant and anti-tyrosinase activities than fruits, seeds and woods. Stem barks were sequentially extracted with n-hexane, ethyl acetate, methanol and water and then the fractionated extracts were subjected to antioxidant and antityrosinase activities testing. The ethyl acetate and methanol extracts of stem barks exhibited higher total phenolic and flavonoid contents and antioxidant and antityrosinase activities than the n-hexane and aqueous extracts. Moreover, ethyl acetate extract of M. kauki stem exhibited the highest antityrosinase activity. It may be a potential source of tyrosinase inhibitors for pharmaceutical and cosmetic applications.
Identifiants
pubmed: 32697742
doi: 10.2478/acph-2021-0009
pii: acph-2021-0009
doi:
Substances chimiques
Antioxidants
0
Biphenyl Compounds
0
Enzyme Inhibitors
0
Flavonoids
0
Phenols
0
Picrates
0
Plant Extracts
0
Solvents
0
1,1-diphenyl-2-picrylhydrazyl
DFD3H4VGDH
Monophenol Monooxygenase
EC 1.14.18.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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