Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.
Calcium
/ metabolism
Cardiac Conduction System Disease
/ genetics
Cardiomyopathy, Dilated
/ pathology
Culture Media
/ pharmacology
Gene Expression Regulation
/ drug effects
Heart
/ drug effects
Humans
Induced Pluripotent Stem Cells
/ cytology
Long QT Syndrome
/ genetics
Membrane Potentials
/ drug effects
Models, Biological
Myocardial Contraction
/ drug effects
Myocytes, Cardiac
/ cytology
Phenotype
Tissue Engineering
cardiomyocyte
dilated cardiomyopathy
disease modeling
engineered heart tissues
induced pluripotent stem cells
long QT syndrome 3
maturation
physiology
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
21 07 2020
21 07 2020
Historique:
received:
25
03
2020
revised:
15
05
2020
accepted:
26
06
2020
entrez:
23
7
2020
pubmed:
23
7
2020
medline:
29
4
2021
Statut:
ppublish
Résumé
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential for the study of human cardiac disorders. However, their physiological immaturity severely limits their utility as a model system and their adoption for drug discovery. Here, we describe maturation media designed to provide oxidative substrates adapted to the metabolic needs of human iPSC (hiPSC)-CMs. Compared with conventionally cultured hiPSC-CMs, metabolically matured hiPSC-CMs contract with greater force and show an increased reliance on cardiac sodium (Na
Identifiants
pubmed: 32697997
pii: S2211-1247(20)30906-2
doi: 10.1016/j.celrep.2020.107925
pmc: PMC7437654
mid: NIHMS1613944
pii:
doi:
Substances chimiques
Culture Media
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107925Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL138539
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132225
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130840
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL141084
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL113601
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128072
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL141019
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests. A patent application related to this work has been submitted.
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