B-Cell-Activating Factor Depletion Ameliorates Aging-Dependent Insulin Resistance via Enhancement of Thermogenesis in Adipose Tissues.
B-cell-activating factor (BAFF)
adipose tissue browning
aging-dependent insulin resistance
brown adipose tissue
non-shivering thermogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Jul 2020
20 Jul 2020
Historique:
received:
09
07
2020
accepted:
17
07
2020
entrez:
24
7
2020
pubmed:
24
7
2020
medline:
20
2
2021
Statut:
epublish
Résumé
Impaired glucose tolerance is a common feature associated with human aging, which is caused by defects in insulin secretion, insulin action or both. Recent studies have suggested that B-cell-activating factor (BAFF), a cytokine that modulates proliferation and differentiation of B cells, and its receptors are expressed in mature adipocytes and preadipocytes, proposing BAFF as a potential regulator of energy metabolism. In this study, we show that systemic BAFF depletion improves aging-dependent insulin resistance. In aged (10-month-old) BAFF
Identifiants
pubmed: 32698539
pii: ijms21145121
doi: 10.3390/ijms21145121
pmc: PMC7404107
pii:
doi:
Substances chimiques
B-Cell Activating Factor
0
Tnfsf13b protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2015R1D1A1A01058699
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