Synthesis, Characterization, and Application of a Highly Hydrophilic Triarylmethyl Radical for Biomedical EPR.
Journal
The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R
Informations de publication
Date de publication:
21 08 2020
21 08 2020
Historique:
pubmed:
24
7
2020
medline:
24
6
2021
entrez:
24
7
2020
Statut:
ppublish
Résumé
Stable tetrathiatriarylmethyl radicals have significantly contributed to the recent progress in biomedical electron paramagnetic resonance (EPR) due to their unmatched stability in biological media and long relaxation times. However, the lipophilic core of the most commonly used structure (Finland trityl) is responsible for its interaction with plasma biomacromolecules, such as albumin, and self-aggregation at high concentrations and/or low pH. While Finland trityl is generally considered inert toward many reactive radical species, we report that sulfite anion radical efficiently substitutes the three carboxyl moieties of Finland trityl with a high rate constant of 3.53 × 10
Identifiants
pubmed: 32698583
doi: 10.1021/acs.joc.0c00557
pmc: PMC7814971
mid: NIHMS1659791
doi:
Substances chimiques
Free Radicals
0
Trityl Compounds
0
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10388-10398Subventions
Organisme : NCI NIH HHS
ID : R01 CA194013
Pays : United States
Organisme : NIBIB NIH HHS
ID : R00 EB023990
Pays : United States
Organisme : NIBIB NIH HHS
ID : K99 EB023990
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104942
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA192064
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB023888
Pays : United States
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