Histone H3.3 phosphorylation amplifies stimulation-induced transcription.

Animals Cell Cycle Proteins / genetics Cells, Cultured Co-Repressor Proteins / genetics DNA-Binding Proteins / genetics Histone-Lysine N-Methyltransferase / genetics Histones / chemistry Humans I-kappa B Kinase / chemistry Macrophages / metabolism Male Methylation Mice Models, Molecular Phosphorylation Transcription, Genetic Up-Regulation / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
07 2020
Historique:
received: 15 02 2019
accepted: 05 05 2020
pubmed: 24 7 2020
medline: 12 1 2021
entrez: 24 7 2020
Statut: ppublish

Résumé

Complex organisms can rapidly induce select genes in response to diverse environmental cues. This regulation occurs in the context of large genomes condensed by histone proteins into chromatin. The sensing of pathogens by macrophages engages conserved signalling pathways and transcription factors to coordinate the induction of inflammatory genes

Identifiants

DOI: 10.1038/s41586-020-2533-0 PMID: 32699416 PMC: PMC7517595
pubmed: 32699416
doi: 10.1038/s41586-020-2533-0
pii: 10.1038/s41586-020-2533-0
pmc: PMC7517595
mid: NIHMS1629344
doi:

Substances chimiques

Cell Cycle Proteins 0
Co-Repressor Proteins 0
DNA-Binding Proteins 0
Histones 0
Zmynd11 protein, mouse 0
Histone-Lysine N-Methyltransferase EC 2.1.1.43
SETD2 protein, human EC 2.1.1.43
I-kappa B Kinase EC 2.7.11.10

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

852-857

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM040922
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA196539
Pays : United States
Organisme : NIGMS NIH HHS
ID : K99 GM113019
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI134632
Pays : United States
Organisme : NIGMS NIH HHS
ID : R00 GM113019
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM124736
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM115882
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148416
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118891
Pays : United States

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Auteurs

Anja Armache (A)

Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY, USA.

Shuang Yang (S)

MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.

Alexia Martínez de Paz (A)

Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-0808-1389

Lexi E Robbins (LE)

Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Ceyda Durmaz (C)

Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Jin Q Cheong (JQ)

Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Arjun Ravishankar (A)

Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0001-8366-4838

Andrew W Daman (AW)

Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Dughan J Ahimovic (DJ)

Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Thaís Klevorn (T)

Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-2765-1626

Yuan Yue (Y)

MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.

Tanja Arslan (T)

Adolf-Butenandt Institute, Ludwig-Maximilians University, Munich, Germany.

Shu Lin (S)

Epigenetics Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.

Tanya Panchenko (T)

Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY, USA.
Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA.

Joel Hrit (J)

Center for Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.

Miao Wang (M)

Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.

Samuel Thudium (S)

Department of Genetics, Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0001-6670-3970

Benjamin A Garcia (BA)

Adolf-Butenandt Institute, Ludwig-Maximilians University, Munich, Germany.

Erica Korb (E)

Department of Genetics, Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Karim-Jean Armache (KJ)

Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.

Scott B Rothbart (SB)

Center for Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.
ORCID: 0000-0003-1631-5392

Sandra B Hake (SB)

Adolf-Butenandt Institute, Ludwig-Maximilians University, Munich, Germany.
Institute for Genetics, Justus-Liebig-University, Giessen, Germany.

C David Allis (CD)

Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0001-7589-713X

Haitao Li (H)

MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China. lht@tsinghua.edu.cn.
ORCID: 0000-0001-6741-293X

Steven Z Josefowicz (SZ)

Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. szj2001@med.cornell.edu.
ORCID: 0000-0001-7453-779X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Histone H3.3 phosphorylation amplifies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Histone H3.3 phosphorylation amplifies...
questionsmedicales.fr › Cellules › Cellules cultivées › Histone H3.3 phosphorylation amplifies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Protéines corépressives › Histone H3.3 phosphorylation amplifies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Histone H3.3 phosphorylation amplifies...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Protein Methyltransferases › Histone méthyltransférases › Histone-lysine N-methyltransferase › Histone H3.3 phosphorylation amplifies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Histone H3.3 phosphorylation amplifies...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Histone H3.3 phosphorylation amplifies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › I-kappa B Kinase › Histone H3.3 phosphorylation amplifies...
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questionsmedicales.fr › Métabolisme › Alkylation › Méthylation › Histone H3.3 phosphorylation amplifies...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Histone H3.3 phosphorylation amplifies...
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