Wernicke-Kleist-Leonhard phenotypes of endogenous psychoses: a review of their validity .

Diagnostic and Statistical Manual of Mental Disorders Humans Phenotype Psychotic Disorders / classification Reproducibility of Results Wernicke Encephalopathy / classification
endogenous psychosis Kleist Leonhard Wernicke affect laden paraphrenia bipolar cataphasia catatonia classification cycloid psychoses deep phenotyping epistemology hebephrenia periodic catatonia phenotype schizophrenia supersensitivity psychosis system schizophrenia unipolar

Journal

Dialogues in clinical neuroscience
ISSN: 1958-5969
Titre abrégé: Dialogues Clin Neurosci
Pays: England
ID NLM: 101238198

Informations de publication

Date de publication:
03 2020
Historique:
entrez: 24 7 2020
pubmed: 24 7 2020
medline: 15 7 2021
Statut: ppublish

Résumé

While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-Leonhard (WKL) pathway has optimized the descriptions of 35 major phenotypes using common medical heuristics on lifelong diachronic observations. Regarding their construct validity, WKL phenotypes have good reliability and predictive and face validity. WKL phenotypes come with remarkable evidence for differential validity on age of onset, familiality, pregnancy complications, precipitating factors, and treatment response. Most impressive is the replicated separation of high- and low-familiality phenotypes. Created in the purest tradition of the biomedical paradigm, the WKL phenotypes deserve to be contrasted as credible alternatives with other approaches currently under discussion.
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Identifiants

DOI: 10.31887/DCNS.2020.22.1/jfoucher PMID: 32699504 PMC: PMC7365293
pubmed: 32699504
doi: 10.31887/DCNS.2020.22.1/jfoucher
pmc: PMC7365293
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

37-49

Informations de copyright

© 2019, AICHServier GroupCopyright © 2019 AICH Servier Group. All rights reserved.

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Auteurs

Jack R Foucher (JR)

ICube - CNRS UMR 7357, neurophysiology, FMTS, University of Strasbourg, France ; CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, France.

Micha Gawlik (M)

Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany.

Julian N Roth (JN)

Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany.

Clément de Crespin de Billy (C)

ICube - CNRS UMR 7357, neurophysiology, FMTS, University of Strasbourg, France; CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, France.

Ludovic C Jeanjean (LC)

IICube - CNRS UMR 7357, neurophysiology, FMTS, University of Strasbourg, France; CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, France.

Alexandre Obrecht (A)

ICube - CNRS UMR 7357, neurophysiology, FMTS, University of Strasbourg, France; Pôle de Psychiatrie, Santé Mentale et Addictologie, University Hospital Strasbourg, France.

Olivier Mainberger (O)

ICube - CNRS UMR 7357, neurophysiology, FMTS, University of Strasbourg, France. CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, France.

Julie M E Clauss (JME)

Pôle de Psychiatrie, Santé Mentale et Addictologie, University Hospital Strasbourg, France. SAGE - CNRS UMR 7363, FMTS, University of Strasbourg, France.

Julien Elowe (J)

Department of Psychiatry, Prangins Psychiatric Hospital (CHUV), Route de Benex, Prangins, Switzerland.

Sébastien Weibel (S)

IPôle de Psychiatrie, Santé Mentale et Addictologie, University Hospital Strasbourg, France; Physiopathologie et Psychopathologie Cognitive de la Schizophrénie - INSERM 1114, FMTS, University of Strasbourg, France.

Benoit Schorr (B)

Pôle de Psychiatrie, Santé Mentale et Addictologie, University Hospital Strasbourg, France; Physiopathologie et Psychopathologie Cognitive de la Schizophrénie - INSERM 1114, FMTS, University of Strasbourg, France.

Marcelo Cetkovich (M)

Institute of Translational and Cognitive Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.

Carlos Morra (C)

ICube - CNRS UMR 7357, neurophysiology, FMTS, University of StInstitute of Translational and Cognitive Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Sanatorio Morra, Córdoba, Argentina.

Federico Rebok (F)

"Servicio de Emergencia", Acute Inpatient Unit, Moyano Neuropsychiatric Hospital, Buenos Aires, Argentina.

Thomas A Ban (TA)

International Network for the History of Neuropsychopharmacology (INHN), Córdoba, Argentina.

Barbara Bollmann (B)

Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Berlin, Germany.

Mathilde M Roser (MM)

Department of Psychiatry, Mondor Hospital France, Creteil, France.

Markus S Hanke (MS)

Universitäre psychiatrische Dienste Bern, Spiez, Switzerland.

Burkhard E Jabs (BE)

Klinik für Psychiatrie and Psychotherapie, Städtisches Klinikum Dresden, Dresden, Germany.

Ernst J Franzek (EJ)

Yes We Can Clinics, Department of Research and Development, Eindhoven, The Netherlands.

Fabrice Berna (F)

Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany; Department of Psychiatry, Prangins Psychiatric Hospital (CHUV), Route de Benex, Prangins, Switzerland.

Bruno Pfuhlmann (B)

IKlinik für Psychiatrie and Psychotherapie, Städtisches Klinikum Dresden, Dresden, Germany.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Vocabulaire contrôlé › Diagnostic and stastistical manual of mental disorders (USA) › Wernicke-Kleist-Leonhard phenotypes of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Wernicke-Kleist-Leonhard phenotypes of...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Wernicke-Kleist-Leonhard phenotypes of...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Troubles psychotiques › Wernicke-Kleist-Leonhard phenotypes of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Wernicke-Kleist-Leonhard phenotypes of...
questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Troubles liés à l'alcool › Encéphalopathie de Gayet-Wernicke › Wernicke-Kleist-Leonhard phenotypes of...