Fibroblast-derived IL-33 is dispensable for lymph node homeostasis but critical for CD8 T-cell responses to acute and chronic viral infection.
Acute Disease
Adaptive Immunity
Animals
CD8-Positive T-Lymphocytes
/ immunology
Chronic Disease
Endothelial Cells
/ immunology
Fibroblasts
/ immunology
Homeostasis
Humans
Immunity, Innate
Interleukin-33
/ deficiency
Lymph Nodes
/ immunology
Lymphocytic Choriomeningitis
/ immunology
Lymphocytic choriomeningitis virus
/ immunology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Models, Immunological
FRC
Interleukin-33
LCMV
alarmin
fibroblastic reticular cells
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
19
09
2019
revised:
02
06
2020
accepted:
21
07
2020
pubmed:
24
7
2020
medline:
23
4
2021
entrez:
24
7
2020
Statut:
ppublish
Résumé
Upon viral infection, stressed or damaged cells can release alarmins like IL-33 that act as endogenous danger signals alerting innate and adaptive immune cells. IL-33 coming from nonhematopoietic cells has been identified as important factor triggering the expansion of antiviral CD8
Identifiants
pubmed: 32700362
doi: 10.1002/eji.201948413
doi:
Substances chimiques
IL33 protein, human
0
Il33 protein, mouse
0
Interleukin-33
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
76-90Subventions
Organisme : European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant
ID : 708715
Organisme : Swiss National Science Foundation (SNF) Sinergia program
ID : CRSII3_160772
Organisme : SNF grant
ID : 166500
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 Wiley-VCH GmbH.
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