MicroRNAs target the Wnt/β‑catenin signaling pathway to regulate epithelial‑mesenchymal transition in cancer (Review).
microRNA
Wnt/β-catenin signaling
epithelialmesenchymal transition
cancer metastasis
cancer therapy
Journal
Oncology reports
ISSN: 1791-2431
Titre abrégé: Oncol Rep
Pays: Greece
ID NLM: 9422756
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
20
03
2020
accepted:
24
06
2020
pubmed:
24
7
2020
medline:
29
10
2020
entrez:
24
7
2020
Statut:
ppublish
Résumé
Epithelial‑mesenchymal transition (EMT), during which cancer cells lose the epithelial phenotype and gain the mesenchymal phenotype, has been verified to result in tumor migration and invasion. Numerous studies have shown that dysregulation of the Wnt/β‑catenin signaling pathway gives rise to EMT, which is characterized by nuclear translocation of β‑catenin and E‑cadherin suppression. Wnt/β‑catenin signaling was confirmed to be affected by microRNAs (miRNAs), several of which are down‑ or upregulated in metastatic cancer cells, indicating their complex roles in Wnt/β‑catenin signaling. In this review, we demonstrated the targets of various miRNAs in altering Wnt/β‑catenin signaling to promote or inhibit EMT, which may elucidate the underlying mechanism of EMT regulation by miRNAs and provide evidence for potential therapeutic targets in the treatment of invasive tumors.
Identifiants
pubmed: 32700744
doi: 10.3892/or.2020.7703
pmc: PMC7448411
doi:
Substances chimiques
CTNNB1 protein, human
0
MicroRNAs
0
Wnt Proteins
0
beta Catenin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1299-1313Références
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