Evaluation of antenatal risk factors for postpartum depression: a secondary cohort analysis of the cluster-randomised GeliS trial.
Anxiety
EPDS
Gestational weight gain
Lifestyle intervention
Obesity prevention
Postpartum depression
Predictor
Routine care
Well-being
Journal
BMC medicine
ISSN: 1741-7015
Titre abrégé: BMC Med
Pays: England
ID NLM: 101190723
Informations de publication
Date de publication:
24 07 2020
24 07 2020
Historique:
received:
20
02
2020
accepted:
23
06
2020
entrez:
25
7
2020
pubmed:
25
7
2020
medline:
11
2
2021
Statut:
epublish
Résumé
Maternal weight variables are important predictors of postpartum depression (PPD). While preliminary evidence points to an association between pre-pregnancy obesity and PPD, the role of excessive gestational weight gain (GWG) on PPD is less studied. In this secondary cohort analysis of the German 'healthy living in pregnancy' (GeliS) trial, we aimed to investigate associations between weight-related variables and PPD and to assess the influence of GWG on the risk for PPD. We included women with normal weight, overweight, and obesity (BMI 18.5-40.0 kg/m Of the total 1583 participants, 45.6% (n = 722) showed excessive GWG and 7.9% (n = 138) experienced PPD. Pre-pregnancy BMI (per 5-unit increase; OR = 1.23, 95% CI 1.08-1.41, p = 0.002) and pre-pregnancy overweight or obesity were significantly positively associated with the odds of developing PPD, particularly among women with an antenatal history of anxiety or depressive symptoms (overweight: OR = 1.93, 95% CI = 1.15-3.22, p = 0.01; obesity: OR = 2.11, 95% CI = 1.13-3.96, p = 0.02). Sociodemographic or lifestyle factors did not additively influence the odds of having PPD. In fully adjusted models, there was no significant evidence that GWG or the occurrence of excessive GWG increased the odds of experiencing PPD (excessive vs. non-excessive: OR = 3.48, 95% CI 0.35-34.94; GWG per 1 kg increase: OR = 1.16, 95% CI 0.94-1.44). Pre-pregnancy overweight or obesity is associated with PPD independent of concurrent risk factors. History of anxiety or depressive symptoms suggests a stress-induced link between pre-pregnancy weight and PPD. NCT01958307 , ClinicalTrials.gov, retrospectively registered on 9 October 2013.
Sections du résumé
BACKGROUND
Maternal weight variables are important predictors of postpartum depression (PPD). While preliminary evidence points to an association between pre-pregnancy obesity and PPD, the role of excessive gestational weight gain (GWG) on PPD is less studied. In this secondary cohort analysis of the German 'healthy living in pregnancy' (GeliS) trial, we aimed to investigate associations between weight-related variables and PPD and to assess the influence of GWG on the risk for PPD.
METHODS
We included women with normal weight, overweight, and obesity (BMI 18.5-40.0 kg/m
RESULTS
Of the total 1583 participants, 45.6% (n = 722) showed excessive GWG and 7.9% (n = 138) experienced PPD. Pre-pregnancy BMI (per 5-unit increase; OR = 1.23, 95% CI 1.08-1.41, p = 0.002) and pre-pregnancy overweight or obesity were significantly positively associated with the odds of developing PPD, particularly among women with an antenatal history of anxiety or depressive symptoms (overweight: OR = 1.93, 95% CI = 1.15-3.22, p = 0.01; obesity: OR = 2.11, 95% CI = 1.13-3.96, p = 0.02). Sociodemographic or lifestyle factors did not additively influence the odds of having PPD. In fully adjusted models, there was no significant evidence that GWG or the occurrence of excessive GWG increased the odds of experiencing PPD (excessive vs. non-excessive: OR = 3.48, 95% CI 0.35-34.94; GWG per 1 kg increase: OR = 1.16, 95% CI 0.94-1.44).
CONCLUSION
Pre-pregnancy overweight or obesity is associated with PPD independent of concurrent risk factors. History of anxiety or depressive symptoms suggests a stress-induced link between pre-pregnancy weight and PPD.
TRIAL REGISTRATION
NCT01958307 , ClinicalTrials.gov, retrospectively registered on 9 October 2013.
Identifiants
pubmed: 32703266
doi: 10.1186/s12916-020-01679-7
pii: 10.1186/s12916-020-01679-7
pmc: PMC7379365
doi:
Banques de données
ClinicalTrials.gov
['NCT01958307']
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
227Subventions
Organisme : Else Kröner-Fresenius Centre for Nutritional Medicine
ID : NA
Pays : International
Organisme : Competence Centre for Nutrition (KErn)
ID : NA
Pays : International
Organisme : Bayerisches Staatsministerium für Ernährung, Landwirtschaft und Forsten (DE)
ID : NA
Pays : International
Organisme : Bavarian State Ministry of Health and Care (Health Initiative "Gesund.Leben.Bayern.")
ID : NA
Pays : International
Organisme : AOK Bayern
ID : NA
Pays : International
Organisme : DEDIPAC consortium by the Joint Programming Initiative (JPI) "A Healthy Diet for a Healthy Life"
ID : NA
Pays : International
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