Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism.
Animals
Breast Neoplasms
/ physiopathology
Disease Models, Animal
Estrogens
/ metabolism
Female
Gene Expression Regulation, Neoplastic
Humans
Mammary Glands, Animal
/ drug effects
Mammary Neoplasms, Animal
/ physiopathology
Mice
Mice, Inbred BALB C
Neutrophils
/ metabolism
Parity
Postpartum Period
Up-Regulation
Estrogen
developmental biology
human
immunology
inflammation
mammary involution
mouse
neutrophils
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
24 07 2020
24 07 2020
Historique:
received:
26
03
2020
accepted:
23
07
2020
pubmed:
25
7
2020
medline:
13
2
2021
entrez:
25
7
2020
Statut:
epublish
Résumé
There is strong evidence that the pro-inflammatory microenvironment during post-partum mammary involution promotes parity-associated breast cancer. Estrogen exposure during mammary involution drives tumor growth through neutrophils' activity. However, how estrogen and neutrophils influence mammary involution are unknown. Combined analysis of transcriptomic, protein, and immunohistochemical data in BALB/c mice showed that estrogen promotes involution by exacerbating inflammation, cell death and adipocytes repopulation. Remarkably, 88% of estrogen-regulated genes in mammary tissue were mediated through neutrophils, which were recruited through estrogen-induced CXCR2 signalling in an autocrine fashion. While neutrophils mediate estrogen-induced inflammation and adipocytes repopulation, estrogen-induced mammary cell death was via lysosome-mediated programmed cell death through upregulation of
Identifiants
pubmed: 32706336
doi: 10.7554/eLife.57274
pii: 57274
pmc: PMC7417171
doi:
pii:
Substances chimiques
Estrogens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education of Singapore
ID : MOE2017-T1-002-08
Pays : International
Organisme : Ministry of Education of Singapore
ID : MOE2017-T1-002-081
Pays : International
Informations de copyright
© 2020, Lim et al.
Déclaration de conflit d'intérêts
CL, YO, ZO, HC, HH, SS, SC, FL, VL No competing interests declared
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