Alamandine attenuates angiotensin II-induced vascular fibrosis via inhibiting p38 MAPK pathway.
Angiotensin II
Animals
Antihypertensive Agents
/ pharmacology
Aorta, Thoracic
/ drug effects
Arterial Pressure
/ drug effects
Cells, Cultured
Disease Models, Animal
Fibrosis
Hypertension
/ chemically induced
Male
Mice, Inbred C57BL
Muscle, Smooth, Vascular
/ drug effects
Myocytes, Smooth Muscle
/ drug effects
Nerve Tissue Proteins
/ genetics
Oligopeptides
/ pharmacology
Phosphorylation
Rats, Sprague-Dawley
Receptors, G-Protein-Coupled
/ genetics
Signal Transduction
Vascular Remodeling
/ drug effects
p38 Mitogen-Activated Protein Kinases
/ metabolism
Alamandine
G protein-coupled receptor
Member D
Vascular fibrosis
Vascular smooth muscle cell
p38 MAPK
Journal
European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354
Informations de publication
Date de publication:
15 Sep 2020
15 Sep 2020
Historique:
received:
18
11
2019
revised:
11
06
2020
accepted:
16
07
2020
pubmed:
25
7
2020
medline:
19
5
2021
entrez:
25
7
2020
Statut:
ppublish
Résumé
Alamandine attenuates hypertension and cardiac remodeling in spontaneously hypertensive rats (SHRs). We examined whether alamandine attenuates vascular remodeling in mice, and regulates angiotensin II (Ang II)-induced fibrosis in rat vascular smooth muscle cells (VSMCs). Alamandine attenuated hypertension in mice induced by Ang II. Ang II increased the fibrosis of thoracic aorta in mice, which was attenuated by alamandine treatment. Increased levels of collagen I, transforming growth factor-β (TGF-β), and connective tissue growth factor (CTGF) levels in thoracic aortas after Ang II treatment in mice were inhibited by alamandine. Ang II-stimulated collagen I, TGF-β, and CTGF level increases were inhibited by alamandine in rat VSMCs. This could be reversed by Mas-related G protein-coupled receptor, member D (MrgD) antagonist D-Pro
Identifiants
pubmed: 32707188
pii: S0014-2999(20)30476-3
doi: 10.1016/j.ejphar.2020.173384
pii:
doi:
Substances chimiques
Antihypertensive Agents
0
Mrgprd protein, mouse
0
Mrgprd protein, rat
0
Nerve Tissue Proteins
0
Oligopeptides
0
Receptors, G-Protein-Coupled
0
alamandine
0
Angiotensin II
11128-99-7
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173384Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.