Fibroblast Growth Factor-14 Acts as Tumor Suppressor in Lung Adenocarcinomas.
A549 Cells
Adenocarcinoma of Lung
/ metabolism
Animals
Cell Movement
/ genetics
Cell Proliferation
/ genetics
Cohort Studies
Down-Regulation
Epithelial-Mesenchymal Transition
/ genetics
Fibroblast Growth Factors
/ genetics
Humans
Kaplan-Meier Estimate
Lung Neoplasms
/ metabolism
Mice
Mice, Inbred NOD
Mice, SCID
Transcriptome
/ genetics
Transfection
Tumor Suppressor Proteins
/ genetics
Xenograft Model Antitumor Assays
fibroblast growth factor 14
lung adenocarcinoma
lung cancer mesenchymal epithelial transition
xenograft model
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
22 07 2020
22 07 2020
Historique:
received:
29
06
2020
revised:
17
07
2020
accepted:
20
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
11
3
2021
Statut:
epublish
Résumé
Investigation of the molecular dynamics in lung cancer is crucial for the development of new treatment strategies. Fibroblast growth factor (FGF) 14 belongs to the FGF family, which might play a crucial role in cancer progression. We analyzed lung adenocarcinoma (LUAC) patients samples and found that FGF14 was downregulated, correlating with reduced survival and oncogenic mutation status. FGF14 overexpression in lung cancer cell lines resulted in decreased proliferation, colony formation, and migration, as well as increased expression of epithelial markers and a decreased expression of mesenchymal markers, indicating a mesenchymal to epithelial transition in vitro. We verified these findings using small interfering RNA against FGF14 and further confirmed the suppressive effect of FGF14 in a
Identifiants
pubmed: 32707902
pii: cells9081755
doi: 10.3390/cells9081755
pmc: PMC7466013
pii:
doi:
Substances chimiques
Tumor Suppressor Proteins
0
fibroblast growth factor 14
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Sci Transl Med. 2017 Nov 15;9(416):
pubmed: 29141888
Oncogenesis. 2019 Nov 6;8(11):66
pubmed: 31695026
BMC Bioinformatics. 2015 May 22;16:169
pubmed: 25994840
Clin Chest Med. 2011 Dec;32(4):669-92
pubmed: 22054879
Science. 2013 Mar 29;339(6127):1546-58
pubmed: 23539594
Ann Glob Health. 2019 Jan 22;85(1):
pubmed: 30741509
Sci Adv. 2020 Jun 05;6(23):eaaz6105
pubmed: 32548260
Cytokine Growth Factor Rev. 2005 Apr;16(2):215-20
pubmed: 15863036
Cells Tissues Organs. 2007;185(1-3):7-19
pubmed: 17587803
J Biol Chem. 2003 Sep 5;278(36):34226-36
pubmed: 12815063
J Cancer. 2020 Jan 1;11(4):819-825
pubmed: 31949485
PLoS One. 2019 Sep 6;14(9):e0222298
pubmed: 31491024
Cancer Med. 2014 Jun;3(3):681-92
pubmed: 24711160
Nat Commun. 2016 Nov 21;7:13424
pubmed: 27869118
Oncol Rep. 2017 Jan;37(1):333-340
pubmed: 28004111
Oncotarget. 2018 Jan 12;9(15):12226-12239
pubmed: 29552305
J Biol Chem. 2013 Jul 5;288(27):19370-85
pubmed: 23640885
Front Cell Neurosci. 2017 Apr 19;11:103
pubmed: 28469558
Cell Death Dis. 2018 Dec 5;9(12):1169
pubmed: 30518868
Nature. 2007 Mar 8;446(7132):153-8
pubmed: 17344846
Oncol Rep. 2016 Aug;36(2):877-85
pubmed: 27373316
Mol Neurobiol. 2016 Dec;53(10):7254-7270
pubmed: 26687232
Pathol Int. 2020 Feb;70(2):101-107
pubmed: 31867792
Wiley Interdiscip Rev Dev Biol. 2015 May-Jun;4(3):215-66
pubmed: 25772309
J Biol Chem. 2008 Mar 14;283(11):7251-60
pubmed: 18178553
PLoS One. 2013 Dec 18;8(12):e82241
pubmed: 24367507
Med Oncol. 2014 Jul;31(7):48
pubmed: 24913812
Mech Dev. 2000 Feb;90(2):283-7
pubmed: 10640713
Clin Lung Cancer. 2012 Mar;13(2):90-5
pubmed: 21959109
Nature. 2008 Oct 23;455(7216):1069-75
pubmed: 18948947
Nature. 2018 Jan 24;553(7689):446-454
pubmed: 29364287
Sci Rep. 2018 Jun 15;8(1):9227
pubmed: 29907753
Hum Mutat. 2009 Sep;30(9):1245-55
pubmed: 19621416
J Cell Physiol. 2007 Nov;213(2):374-83
pubmed: 17680632
Am J Respir Crit Care Med. 2015 Feb 15;191(4):437-47
pubmed: 25536148
Eur J Cancer. 2012 Jul;48(10):1558-69
pubmed: 21852110
Cell Mol Life Sci. 2012 Oct;69(20):3429-56
pubmed: 22945800
Oncogene. 2014 Jun 26;33(26):3432-40
pubmed: 23934190
Mol Cancer Res. 2017 Feb;15(2):201-212
pubmed: 28108627
Oncol Lett. 2016 Jul;12(1):473-478
pubmed: 27347167
Br J Cancer. 2017 May 9;116(10):1350-1357
pubmed: 28419078
J Clin Invest. 2020 Jul 1;130(7):3560-3575
pubmed: 32229721
J Biol Chem. 2009 Jun 26;284(26):17883-96
pubmed: 19406745
Mol Biol Cell. 2009 Nov;20(22):4751-65
pubmed: 19759179
Curr Biol. 2001 May 15;11(10):793-7
pubmed: 11378392
Br J Cancer. 2010 Jan 5;102(1):87-96
pubmed: 19935792
Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):154-159
pubmed: 27994149
Nat Rev Cancer. 2010 Feb;10(2):116-29
pubmed: 20094046
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14116-21
pubmed: 16963563
J Biol Chem. 2002 Dec 20;277(51):49111-9
pubmed: 12244047
Genome Res. 2007 Nov;17(11):1586-95
pubmed: 17908822
Cancer Res. 2018 Nov 1;78(21):6320-6328
pubmed: 30232219