Profiling of Mitochondrial DNA Heteroplasmy in a Prospective Oral Squamous Cell Carcinoma Study.
NGS
OSCC
haplogroup
heteroplasmy
mitochondrial DNA
mtDNA
next generation sequencing
oral cancer
oral squamous cell carcinoma
survival analysis
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
17 Jul 2020
17 Jul 2020
Historique:
received:
23
06
2020
revised:
13
07
2020
accepted:
15
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
28
7
2020
Statut:
epublish
Résumé
While a shift in energy metabolism is essential to cancers, the knowledge about the involvement of the mitochondrial genome in tumorigenesis and progression in oral squamous cell carcinoma (OSCC) is still very limited. In this study, we evaluated 37 OSCC tumors and the corresponding benign mucosa tissue pairs by deep sequencing of the complete mitochondrial DNA (mtDNA). After extensive quality control, we identified 287 variants, 137 in tumor and 150 in benign samples exceeding the 1% threshold. Variant heteroplasmy levels were significantly increased in cancer compared to benign tissues (
Identifiants
pubmed: 32708892
pii: cancers12071933
doi: 10.3390/cancers12071933
pmc: PMC7409097
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Translational Research Grant of the County of Tyrol, Austria
ID : 273-1-15
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