Helmut Klocker

Affiliations

University Hospital for Urology, Division of Experimental Urology, Department of Surgery, Medical University Innsbruck, Anichstraße 35, A-6020, Innsbruck, Austria. helmut.klocker@i-med.ac.at.

ORCID: http://orcid.org/0000-0001-7732-9443

Publications (27)

OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation.

Nature communications

Avec: Bernd Schöpf , Hansi Weissensteiner , Georg Schäfer , Federica Fazzini , Pornpimol Charoentong , Andreas Naschberger , Bernhard Rupp , Liane Fendt , Valesca Bukur , Irina Giese , Patrick Sorn , Ana Carolina Sant'Anna-Silva , Javier Iglesias-Gonzalez , Ugur Sahin , Florian Kronenberg , Erich Gnaiger , Helmut Klocker

Targeting the glucocorticoid receptor signature gene Mono Amine Oxidase-A enhances the efficacy of chemo- and anti-androgen therapy in advanced prostate cancer.

Oncogene

Avec: Martin Puhr , Andrea Eigentler , Florian Handle , Hubert Hackl , Christian Ploner , Isabel Heidegger , Georg Schaefer , Maximilian P Brandt , Julia Hoefer , Gabri Van der Pluijm , Helmut Klocker

The HeyL-Aromatase Axis Promotes Cancer Stem Cell Properties by Endogenous Estrogen-Induced Autophagy in Castration-Resistant Prostate Cancer.

Frontiers in oncology

Avec: Qimei Lin , Jiasong Cao , Xiaoling Du , Kuo Yang , Yongmei Shen , Weishu Wang , Helmut Klocker , Jiandang Shi , Ju Zhang

STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway.

Molecular cancer

Avec: Jan Pencik , Cecile Philippe , Michaela Schlederer , Emine Atas , Matteo Pecoraro , Sandra Grund-Gröschke , Wen Jess Li , Amanda Tracz , Isabel Heidegger , Sabine Lagger , Karolína Trachtová , Monika Oberhuber , Ellen Heitzer , Osman Aksoy , Heidi A Neubauer , Bettina Wingelhofer , Anna Orlova , Nadine Witzeneder , Thomas Dillinger , Elisa Redl , Georg Greiner , David D'Andrea , Johnny R Östman , Simone Tangermann , Ivana Hermanova , Georg Schäfer , Felix Sternberg , Elena E Pohl , Christina Sternberg , Adam Varady , Jaqueline Horvath , Dagmar Stoiber , Tim I Malcolm , Suzanne D Turner , Eileen E Parkes , Brigitte Hantusch , Gerda Egger , Stefan Rose-John , Valeria Poli , Suneil Jain , Chris W D Armstrong , Gregor Hoermann , Vincent Goffin , Fritz Aberger , Richard Moriggl , Arkaitz Carracedo , Cathal McKinney , Richard D Kennedy , Helmut Klocker , Michael R Speicher , Dean G Tang , Ali A Moazzami , David M Heery , Marcus Hacker , Lukas Kenner

Dual Inhibitory Action of a Novel AKR1C3 Inhibitor on Both Full-Length AR and the Variant AR-V7 in Enzalutamide Resistant Metastatic Castration Resistant Prostate Cancer.

Cancers

Avec: Mona Kafka , Fabian Mayr , Veronika Temml , Gabriele Möller , Jerzy Adamski , Julia Höfer , Stefan Schwaiger , Isabel Heidegger , Barbara Matuszczak , Daniela Schuster , Helmut Klocker , Jasmin Bektic , Hermann Stuppner , Iris E Eder

Implications of Standardized Uptake Values of Oral Squamous Cell Carcinoma in PET-CT on Prognosis, Tumor Characteristics and Mitochondrial DNA Heteroplasmy.

Cancers

Avec: Lukas Latzko , Bernd Schöpf , Hansi Weissensteiner , Federica Fazzini , Liane Fendt , Eberhard Steiner , Emanuel Bruckmoser , Georg Schäfer , Roy-Cesar Moncayo , Helmut Klocker , Johannes Laimer

Validating fPSA Glycoprofile as a Prostate Cancer Biomarker to Avoid Unnecessary Biopsies and Re-Biopsies.

Cancers

Avec: Tomas Bertok , Eduard Jane , Aniko Bertokova , Lenka Lorencova , Peter Zvara , Bozena Smolkova , Radek Kucera , Helmut Klocker , Jan Tkac

Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis.

Cell communication and signaling : CCS

Avec: Hannes Neuwirt , Jan Bouchal , Gvantsa Kharaishvili , Christian Ploner , Karin Jöhrer , Florian Pitterl , Anja Weber , Helmut Klocker , Iris E Eder

The transcription factor CUX1 negatively regulates invasion in castrate resistant prostate cancer.

Oncotarget

Avec: Emma R Dorris , Amanda O'Neill , Ann Treacy , Helmut Klocker , Omri Teltsh , Elaine Kay , R William Watson

Development and validation of a novel multivariate risk score to guide biopsy decision for the diagnosis of clinically significant prostate cancer.

BJUI compass

Avec: Helmut Klocker , Bruno Golding , Stephan Weber , Eberhard Steiner , Pierre Tennstedt , Thomas Keller , Ralph Schiess , Silke Gillessen , Wolfgang Horninger , Thomas Steuber

Low Cycle Fatigue of G20Mn5 Cast Steel Relation between Microstructure and Fatigue Life.

Materials (Basel, Switzerland)

Avec: Antonin Bermond , Claire Roume , Jacques Stolarz , Matthieu Lenci , Jean-François Carton , Helmut Klocker

An NMR-based metabolic signature to identify clinically significant prostate cancer in patients undergoing biopsy.

The Journal of clinical endocrinology and metabolism

Avec: Michael Ladurner , Tobias Ameismeier , Helmut Klocker , Eberhard Steiner , Helga Hauffe , Gerhard P Aigner , Hannes Neuwirt , Tina Böld , Selina Strathmeyer , Isabel Heidegger , Diana Drettwan , Iris E Eder

Emerging promising biomarkers for treatment decision in metastatic castration-resistant prostate cancer.

Urologic oncology

Avec: Mona Kafka , Iris E Eder , Helmut Klocker , Isabel Heidegger

The Impact of Cand1 in Prostate Cancer.

Cancers

Avec: Andrea Eigentler , Piotr Tymoszuk , Johanna Zwick , Arndt A Schmitz , Andreas Pircher , Florian Kocher , Andreas Schlicker , Ralf Lesche , Georg Schäfer , Igor Theurl , Helmut Klocker , Isabel Heidegger

Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer.

The Journal of clinical investigation

Avec: Donghyun D Lee , Martin Komosa , Sumedha Sudhaman , Ricardo Leão , Cindy H Zhang , Joana D Apolonio , Thomas Hermanns , Peter J Wild , Helmut Klocker , Farshad Nassiri , Gelareh Zadeh , Bill H Diplas , Hai Yan , Steven Gallinger , Trevor J Pugh , Vijay Ramaswamy , Michael D Taylor , Pedro Castelo-Branco , Nuno Miguel Nunes , Uri Tabori

Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells.

Cancers

Avec: Ana Carolina B Sant'Anna-Silva , Juan A Perez-Valencia , Marco Sciacovelli , Claude Lalou , Saharnaz Sarlak , Laura Tronci , Efterpi Nikitopoulou , Andras T Meszaros , Christian Frezza , Rodrigue Rossignol , Erich Gnaiger , Helmut Klocker

Integrating Serum Biomarkers into Prediction Models for Biochemical Recurrence Following Radical Prostatectomy.

Cancers

Avec: Shirin Moghaddam , Amirhossein Jalali , Amanda O'Neill , Lisa Murphy , Laura Gorman , Anne-Marie Reilly , Áine Heffernan , Thomas Lynch , Richard Power , Kieran J O'Malley , Kristin A Taskèn , Viktor Berge , Vivi-Ann Solhaug , Helmut Klocker , T Brendan Murphy , R William Watson

Effects of cycling and rowing on serum concentrations of prostate-specific antigen: A randomized study of 101 male subjects.

The Prostate

Avec: Andreas Lunacek , Mathias Tischler , Christof Mrstik , Doris Hebenstreit , Reinhard Oeser , Jasmin Bektic , Helmut Klocker , Wolfgang Horninger , Eugen Plas

Glycoprofiling of proteins as prostate cancer biomarkers: A multinational population study.

PloS one

Avec: Andrea Pinkeova , Adela Tomikova , Aniko Bertokova , Eva Fabinyova , Radka Bartova , Eduard Jane , Stefania Hroncekova , Karl-Dietrich Sievert , Roman Sokol , Michal Jirasko , Radek Kucera , Iris E Eder , Wolfgang Horninger , Helmut Klocker , Petra Ďubjaková , Juraj Fillo , Tomas Bertok , Jan Tkac

Profiling of Mitochondrial DNA Heteroplasmy in a Prospective Oral Squamous Cell Carcinoma Study.

Cancers

Avec: Liane Fendt , Federica Fazzini , Hansi Weissensteiner , Emanuel Bruckmoser , Sebastian Schönherr , Georg Schäfer , Jamie Lee Losso , Gertraud A Streiter , Claudia Lamina , Michael Rasse , Helmut Klocker , Barbara Kofler , Anita Kloss-Brandstätter , Christian W Huck , Florian Kronenberg , Johannes Laimer

KDM5D predicts response to docetaxel chemotherapy in metastatic castration resistant prostate cancer patients.

Translational andrology and urology

Avec: Georg Schäfer , Nikola Bednarova , Axel Heidenreich , Helmut Klocker , Isabel Heidegger

Validation of Cell-Free RNA and Circulating Tumor Cells for Molecular Marker Analysis in Metastatic Prostate Cancer.

Biomedicines

Avec: Michael Ladurner , Manuel Wieser , Andrea Eigentler , Martin Seewald , Gabriele Dobler , Hannes Neuwirt , Mona Kafka , Isabel Heidegger , Wolfgang Horninger , Jasmin Bektic , Helmut Klocker , Peter Obrist , Iris E Eder

Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer.

Molecular cancer

Avec: Isabel Heidegger , Georgios Fotakis , Anne Offermann , Jermaine Goveia , Sophia Daum , Stefan Salcher , Asma Noureen , Hetty Timmer-Bosscha , Georg Schäfer , Annemiek Walenkamp , Sven Perner , Aleksandar Beatovic , Matthieu Moisse , Christina Plattner , Anne Krogsdam , Johannes Haybaeck , Sieghart Sopper , Stefanie Thaler , Markus A Keller , Helmut Klocker , Zlatko Trajanoski , Dominik Wolf , Andreas Pircher

The Oncogenic Protein Kinase/ATPase RIOK1 Is Up-Regulated via the c-myc/E2F Transcription Factor Axis in Prostate Cancer.

The American journal of pathology

Avec: Florian Handle , Martin Puhr , Martina Gruber , Chiara Andolfi , Georg Schäfer , Helmut Klocker , Johannes Haybaeck , Peter De Wulf , Zoran Culig

Metformin Overcomes the Consequences of NKX3.1 Loss to Suppress Prostate Cancer Progression.

European urology

Avec: Alexandros Papachristodoulou , Isabel Heidegger , Renu K Virk , Matteo Di Bernardo , Jaime Y Kim , Caroline Laplaca , Florencia Picech , Georg Schäfer , Guarionex Joel De Castro , Hanina Hibshoosh , Massimo Loda , Helmut Klocker , Mark A Rubin , Tian Zheng , Mitchell C Benson , James M McKiernan , Aditya Dutta , Cory Abate-Shen

Therapy-Induced Stromal Senescence Promoting Aggressiveness of Prostate and Ovarian Cancer.

Cells

Avec: Elisa Pardella , Erica Pranzini , Ilaria Nesi , Matteo Parri , Pietro Spatafora , Eugenio Torre , Angela Muccilli , Francesca Castiglione , Massimiliano Fambrini , Flavia Sorbi , Paolo Cirri , Anna Caselli , Martin Puhr , Helmut Klocker , Sergio Serni , Giovanni Raugei , Francesca Magherini , Maria Letizia Taddei

Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer.

Cell reports. Medicine

Avec: Jing Wang , Jing Wei , Tianjie Pu , Alan Zeng , Varsha Karthikeyan , Baron Bechtold , Karen Vo , Jingrui Chen , Tzu-Ping Lin , Amy P Chang , Eva Corey , Martin Puhr , Helmut Klocker , Zoran Culig , Tyler Bland , Boyang Jason Wu

Réseau de co-auteurs

Isabel Heidegger 10 collaborations

Georg Schäfer 9 collaborations

Iris E Eder 6 collaborations

Martin Puhr 4 collaborations

Wolfgang Horninger 4 collaborations

Hansi Weissensteiner 3 collaborations

Federica Fazzini 3 collaborations

Liane Fendt 3 collaborations

Andrea Eigentler 3 collaborations

Mona Kafka 3 collaborations

Jasmin Bektic 3 collaborations

Eberhard Steiner 3 collaborations

Hannes Neuwirt 3 collaborations

Bernd Schöpf 2 collaborations

Florian Kronenberg 2 collaborations

Erich Gnaiger 2 collaborations

Florian Handle 2 collaborations

Christian Ploner 2 collaborations

Emanuel Bruckmoser 2 collaborations

Johannes Laimer 2 collaborations

Tomas Bertok 2 collaborations

Eduard Jane 2 collaborations

Aniko Bertokova 2 collaborations

Radek Kucera 2 collaborations

Jan Tkac 2 collaborations

Amanda O'Neill 2 collaborations

R William Watson 2 collaborations

Michael Ladurner 2 collaborations

Andreas Pircher 2 collaborations

Johannes Haybaeck 2 collaborations

Zoran Culig 2 collaborations

Pornpimol Charoentong 1 collaboration

Andreas Naschberger 1 collaboration

Bernhard Rupp 1 collaboration

Valesca Bukur 1 collaboration

Irina Giese 1 collaboration

Patrick Sorn 1 collaboration

Ana Carolina Sant'Anna-Silva 1 collaboration

Javier Iglesias-Gonzalez 1 collaboration

Ugur Sahin 1 collaboration

Hubert Hackl 1 collaboration

Georg Schaefer 1 collaboration

Maximilian P Brandt 1 collaboration

Julia Hoefer 1 collaboration

Gabri Van der Pluijm 1 collaboration

Qimei Lin 1 collaboration

Jiasong Cao 1 collaboration

Xiaoling Du 1 collaboration

Kuo Yang 1 collaboration

Yongmei Shen 1 collaboration

Weishu Wang 1 collaboration

Jiandang Shi 1 collaboration

Ju Zhang 1 collaboration

Jan Pencik 1 collaboration

Cecile Philippe 1 collaboration

Michaela Schlederer 1 collaboration

Emine Atas 1 collaboration

Matteo Pecoraro 1 collaboration

Sandra Grund-Gröschke 1 collaboration

Wen Jess Li 1 collaboration

Amanda Tracz 1 collaboration

Sabine Lagger 1 collaboration

Karolína Trachtová 1 collaboration

Monika Oberhuber 1 collaboration

Ellen Heitzer 1 collaboration

Osman Aksoy 1 collaboration

Heidi A Neubauer 1 collaboration

Bettina Wingelhofer 1 collaboration

Anna Orlova 1 collaboration

Nadine Witzeneder 1 collaboration

Thomas Dillinger 1 collaboration

Elisa Redl 1 collaboration

Georg Greiner 1 collaboration

David D'Andrea 1 collaboration

Johnny R Östman 1 collaboration

Simone Tangermann 1 collaboration

Ivana Hermanova 1 collaboration

Felix Sternberg 1 collaboration

Elena E Pohl 1 collaboration

Christina Sternberg 1 collaboration

Adam Varady 1 collaboration

Jaqueline Horvath 1 collaboration

Dagmar Stoiber 1 collaboration

Tim I Malcolm 1 collaboration

Suzanne D Turner 1 collaboration

Eileen E Parkes 1 collaboration

Brigitte Hantusch 1 collaboration

Gerda Egger 1 collaboration

Stefan Rose-John 1 collaboration

Valeria Poli 1 collaboration

Suneil Jain 1 collaboration

Chris W D Armstrong 1 collaboration

Gregor Hoermann 1 collaboration

Vincent Goffin 1 collaboration

Fritz Aberger 1 collaboration

Richard Moriggl 1 collaboration

Arkaitz Carracedo 1 collaboration

Cathal McKinney 1 collaboration

Richard D Kennedy 1 collaboration

Michael R Speicher 1 collaboration

Dean G Tang 1 collaboration

Ali A Moazzami 1 collaboration

David M Heery 1 collaboration

Marcus Hacker 1 collaboration

Lukas Kenner 1 collaboration

Fabian Mayr 1 collaboration

Veronika Temml 1 collaboration

Gabriele Möller 1 collaboration

Jerzy Adamski 1 collaboration

Julia Höfer 1 collaboration

Stefan Schwaiger 1 collaboration

Barbara Matuszczak 1 collaboration

Daniela Schuster 1 collaboration

Hermann Stuppner 1 collaboration

Lukas Latzko 1 collaboration

Roy-Cesar Moncayo 1 collaboration

Lenka Lorencova 1 collaboration

Peter Zvara 1 collaboration

Bozena Smolkova 1 collaboration

Jan Bouchal 1 collaboration

Gvantsa Kharaishvili 1 collaboration

Karin Jöhrer 1 collaboration

Florian Pitterl 1 collaboration

Anja Weber 1 collaboration

Emma R Dorris 1 collaboration

Ann Treacy 1 collaboration

Omri Teltsh 1 collaboration

Elaine Kay 1 collaboration

Bruno Golding 1 collaboration

Stephan Weber 1 collaboration

Pierre Tennstedt 1 collaboration

Thomas Keller 1 collaboration

Ralph Schiess 1 collaboration

Silke Gillessen 1 collaboration

Thomas Steuber 1 collaboration

Antonin Bermond 1 collaboration

Claire Roume 1 collaboration

Jacques Stolarz 1 collaboration

Matthieu Lenci 1 collaboration

Jean-François Carton 1 collaboration

Tobias Ameismeier 1 collaboration

Helga Hauffe 1 collaboration

Gerhard P Aigner 1 collaboration

Tina Böld 1 collaboration

Selina Strathmeyer 1 collaboration

Diana Drettwan 1 collaboration

Piotr Tymoszuk 1 collaboration

Johanna Zwick 1 collaboration

Arndt A Schmitz 1 collaboration

Florian Kocher 1 collaboration

Andreas Schlicker 1 collaboration

Ralf Lesche 1 collaboration

Igor Theurl 1 collaboration

Donghyun D Lee 1 collaboration

Martin Komosa 1 collaboration

Sumedha Sudhaman 1 collaboration

Ricardo Leão 1 collaboration

Cindy H Zhang 1 collaboration

Joana D Apolonio 1 collaboration

Thomas Hermanns 1 collaboration

Peter J Wild 1 collaboration

Farshad Nassiri 1 collaboration

Gelareh Zadeh 1 collaboration

Bill H Diplas 1 collaboration

Hai Yan 1 collaboration

Steven Gallinger 1 collaboration

Trevor J Pugh 1 collaboration

Vijay Ramaswamy 1 collaboration

Michael D Taylor 1 collaboration

Pedro Castelo-Branco 1 collaboration

Nuno Miguel Nunes 1 collaboration

Uri Tabori 1 collaboration

Ana Carolina B Sant'Anna-Silva 1 collaboration

Juan A Perez-Valencia 1 collaboration

Marco Sciacovelli 1 collaboration

Claude Lalou 1 collaboration

Saharnaz Sarlak 1 collaboration

Laura Tronci 1 collaboration

Efterpi Nikitopoulou 1 collaboration

Andras T Meszaros 1 collaboration

Christian Frezza 1 collaboration

Rodrigue Rossignol 1 collaboration

Shirin Moghaddam 1 collaboration

Amirhossein Jalali 1 collaboration

Lisa Murphy 1 collaboration

Laura Gorman 1 collaboration

Anne-Marie Reilly 1 collaboration

Áine Heffernan 1 collaboration

Thomas Lynch 1 collaboration

Richard Power 1 collaboration

Kieran J O'Malley 1 collaboration

Kristin A Taskèn 1 collaboration

Viktor Berge 1 collaboration

Vivi-Ann Solhaug 1 collaboration

T Brendan Murphy 1 collaboration

Andreas Lunacek 1 collaboration

Mathias Tischler 1 collaboration

Christof Mrstik 1 collaboration

Doris Hebenstreit 1 collaboration

Reinhard Oeser 1 collaboration

Eugen Plas 1 collaboration

Andrea Pinkeova 1 collaboration

Adela Tomikova 1 collaboration

Eva Fabinyova 1 collaboration

Radka Bartova 1 collaboration

Stefania Hroncekova 1 collaboration

Karl-Dietrich Sievert 1 collaboration

Roman Sokol 1 collaboration

Michal Jirasko 1 collaboration

Petra Ďubjaková 1 collaboration

Juraj Fillo 1 collaboration

Sebastian Schönherr 1 collaboration

Jamie Lee Losso 1 collaboration

Gertraud A Streiter 1 collaboration

Claudia Lamina 1 collaboration

Michael Rasse 1 collaboration

Barbara Kofler 1 collaboration

Anita Kloss-Brandstätter 1 collaboration

Christian W Huck 1 collaboration

Nikola Bednarova 1 collaboration

Axel Heidenreich 1 collaboration

Manuel Wieser 1 collaboration

Martin Seewald 1 collaboration

Gabriele Dobler 1 collaboration

Peter Obrist 1 collaboration

Georgios Fotakis 1 collaboration

Anne Offermann 1 collaboration

Jermaine Goveia 1 collaboration

Sophia Daum 1 collaboration

Stefan Salcher 1 collaboration

Asma Noureen 1 collaboration

Hetty Timmer-Bosscha 1 collaboration

Annemiek Walenkamp 1 collaboration

Sven Perner 1 collaboration

Aleksandar Beatovic 1 collaboration

Matthieu Moisse 1 collaboration

Christina Plattner 1 collaboration

Anne Krogsdam 1 collaboration

Sieghart Sopper 1 collaboration

Stefanie Thaler 1 collaboration

Markus A Keller 1 collaboration

Zlatko Trajanoski 1 collaboration

Dominik Wolf 1 collaboration

Martina Gruber 1 collaboration

Chiara Andolfi 1 collaboration

Peter De Wulf 1 collaboration

Alexandros Papachristodoulou 1 collaboration

Renu K Virk 1 collaboration

Matteo Di Bernardo 1 collaboration

Jaime Y Kim 1 collaboration

Caroline Laplaca 1 collaboration

Florencia Picech 1 collaboration

Guarionex Joel De Castro 1 collaboration

Hanina Hibshoosh 1 collaboration

Massimo Loda 1 collaboration

Mark A Rubin 1 collaboration

Tian Zheng 1 collaboration

Mitchell C Benson 1 collaboration

James M McKiernan 1 collaboration

Aditya Dutta 1 collaboration

Cory Abate-Shen 1 collaboration

Elisa Pardella 1 collaboration

Erica Pranzini 1 collaboration

Ilaria Nesi 1 collaboration

Matteo Parri 1 collaboration

Pietro Spatafora 1 collaboration

Eugenio Torre 1 collaboration

Angela Muccilli 1 collaboration

Francesca Castiglione 1 collaboration

Massimiliano Fambrini 1 collaboration

Flavia Sorbi 1 collaboration

Paolo Cirri 1 collaboration

Anna Caselli 1 collaboration

Sergio Serni 1 collaboration

Giovanni Raugei 1 collaboration

Francesca Magherini 1 collaboration

Maria Letizia Taddei 1 collaboration

Jing Wang 1 collaboration

Jing Wei 1 collaboration

Tianjie Pu 1 collaboration

Alan Zeng 1 collaboration

Varsha Karthikeyan 1 collaboration

Baron Bechtold 1 collaboration

Karen Vo 1 collaboration

Jingrui Chen 1 collaboration

Tzu-Ping Lin 1 collaboration

Amy P Chang 1 collaboration

Eva Corey 1 collaboration

Tyler Bland 1 collaboration

Boyang Jason Wu 1 collaboration