Time-Restricted G-Protein Signaling Pathways via GPR176, G
G-protein
GPR176
Gz
N-glycosylation
RGS16
circadian clock
orphan GPCR
suprachiasmatic nucleus
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Jul 2020
17 Jul 2020
Historique:
received:
27
06
2020
revised:
15
07
2020
accepted:
16
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
17
2
2021
Statut:
epublish
Résumé
G-protein-coupled receptors (GPCRs) are an important source of drug targets with diverse therapeutic applications. However, there are still more than one hundred orphan GPCRs, whose ligands and functions remain unidentified. The suprachiasmatic nucleus (SCN) is the central circadian clock of the brain, directing daily rhythms in activity-rest behavior and physiology. Malfunction of the circadian clock has been linked to a wide variety of diseases, including sleep-wake disorders, obesity, diabetes, cancer, and hypertension, making the circadian clock an intriguing target for drug development. The orphan receptor GPR176 is an SCN-enriched orphan GPCR that sets the pace of the circadian clock. GPR176 undergoes asparagine (
Identifiants
pubmed: 32709014
pii: ijms21145055
doi: 10.3390/ijms21145055
pmc: PMC7404074
pii:
doi:
Substances chimiques
RGS Proteins
0
RGS16 protein
0
Receptors, G-Protein-Coupled
0
Cyclic AMP
E0399OZS9N
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : 17H01524
Organisme : The Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : 15H05933
Organisme : The Project for Elucidating and Controlling Mechanisms of Ageing and Longevity of the Japan Agency for Medical Research and Development
ID : JP19gm5010002
Organisme : The Basis for Supporting Innovative Drug Discovery and Life Science Research program of the Japan Agency for Medical Research and Development
ID : JP19am0101092
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