Decrypting the Origin and Pathogenesis in Pregnant Ewes of a New Ovine Pestivirus Closely Related to Classical Swine Fever Virus.
Abortion, Veterinary
/ virology
Animals
Antibodies, Neutralizing
/ immunology
Antibody Formation
/ immunology
Classical Swine Fever Virus
/ immunology
Cross Reactions
/ immunology
Enzyme-Linked Immunosorbent Assay
/ veterinary
Female
Italy
Pestivirus
/ genetics
Pestivirus Infections
/ veterinary
Phylogeny
Pregnancy
RNA, Viral
/ genetics
Real-Time Polymerase Chain Reaction
Sheep
/ virology
Sheep Diseases
/ virology
CSFV
OVPV
congenital persistent infection
cross-reactivity
evolution
pestivirus
phylodynamic
trans-placental transmission
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
17 07 2020
17 07 2020
Historique:
received:
03
07
2020
revised:
13
07
2020
accepted:
15
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
23
2
2021
Statut:
epublish
Résumé
This study shows the origin and the pathogenic role of a novel ovine pestivirus (OVPV) isolated in 2017 in Italy, as a pathogenic agent causing severe abortions after infection in pregnant ewes and high capacity for virus trans-placental transmission as well as the birth of lambs suffering OVPV-persistent infection. The OVPV infection induced early antibody response detected by the specific ELISA against classical swine fever virus (CSFV), another important virus affecting swine. The neutralizing antibody response were similar against CSFV strains from genotype 2 and the OVPV. These viruses showed high identity in the B/C domain of the E2-glycoprotein. Close molecular diagnostics cross-reactivity between CSFV and OVPV was found and a new OVPV molecular assay was developed. The phylodynamic analysis showed that CSFV seems to have emerged as the result of an inter-species jump of Tunisian sheep virus (TSV) from sheep to pigs. The OVPV and the CSFV share the TSV as a common ancestor, emerging around 300 years ago. This suggests that the differentiation of TSV into two dangerous new viruses for animal health (CSFV and OVPV) was likely favored by human intervention for the close housing of multiple species for intensive livestock production.
Identifiants
pubmed: 32709168
pii: v12070775
doi: 10.3390/v12070775
pmc: PMC7411581
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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