Patient-reported Outcomes of Patients With Breast Cancer During the COVID-19 Outbreak in the Epicenter of China: A Cross-sectional Survey Study.
Adult
Aged
Anxiety
/ epidemiology
Betacoronavirus
/ immunology
Breast Neoplasms
/ immunology
COVID-19
China
/ epidemiology
Coronavirus Infections
/ epidemiology
Cross-Sectional Studies
Depression
/ epidemiology
Female
Health Services Accessibility
/ standards
Humans
Infection Control
/ standards
Male
Middle Aged
Pandemics
/ prevention & control
Patient Reported Outcome Measures
Pneumonia, Viral
/ epidemiology
Risk Factors
SARS-CoV-2
Sleep Initiation and Maintenance Disorders
/ epidemiology
Stress, Psychological
/ epidemiology
Surveys and Questionnaires
/ statistics & numerical data
Breast cancer
COVID-19
Epicenter
Psychological status
Journal
Clinical breast cancer
ISSN: 1938-0666
Titre abrégé: Clin Breast Cancer
Pays: United States
ID NLM: 100898731
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
06
04
2020
revised:
13
05
2020
accepted:
03
06
2020
pubmed:
28
7
2020
medline:
21
10
2020
entrez:
26
7
2020
Statut:
ppublish
Résumé
We aimed to analyze the psychological status in patients with breast cancer (BC) in the epicenter of the coronavirus disease 2019 (COVID-19) pandemic. A total of 658 individuals were recruited from multiple BC centers in Hubei Province. Online questionnaires were conducted, and these included demographic information, clinical features, and 4 patient-reported outcome scales (Generalized Anxiety Disorder Questionnaire [GAD-7], Patient Health Questionnaire [PHQ-9], Insomnia Severity Index [ISI], and Impact of Events Scale-Revised [IES-R]). Multivariable logistic regression analysis was designed to identify potential factors on mental health outcomes. Questionnaires were collected from February 16, 2020 to February 19, 2020, the peak time point of the COVID-19 outbreak in China. Of patients with BC, 46.2% had to modify planned necessary anti-cancer treatment during the outbreak. Severe anxiety and severe depression were reported by 8.9% and 9.3% of patients, respectively. Severe distress and insomnia were reported by 20.8% and 4.0% of patients, respectively. Multivariable logistic regression analysis demonstrated poor general condition, shorter duration after BC diagnosis, aggressive BC molecular subtypes, and close contact with patients with COVID-19 as independent factors associated with anxiety. Poor general condition and central venous catheter flushing delay were factors that were independently associated with depression. In terms of insomnia, poor generation condition was the only associated independent factor. Poor physical condition and treatment discontinuation were underlying risk factors for distress based on multivariable analysis. High rates of anxiety, depression, distress, and insomnia were observed in patients with BC during the COVID-19 outbreak. Special attention should be paid to the psychological status of patients with BC, especially those with poor general condition, treatment discontinuation, aggressive molecular subtypes, and metastatic BC.
Identifiants
pubmed: 32709505
pii: S1526-8209(20)30147-6
doi: 10.1016/j.clbc.2020.06.003
pmc: PMC7275993
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e651-e662Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
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