SEPSIS project: a protocol for studying biomarkers of neonatal sepsis and immune responses of infants in a malaria-endemic region.
immunology
neonatal intensive & critical care
neonatology
paediatric infectious disease & immunisation
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
23 07 2020
23 07 2020
Historique:
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
15
5
2021
Statut:
epublish
Résumé
Neonatal sepsis outreaches all causes of neonatal mortality worldwide and remains a major societal burden in low and middle income countries. In addition to limited resources, endemic morbidities, such as malaria and prematurity, predispose neonates and infants to invasive infection by altering neonatal immune response to pathogens. Nevertheless, thoughtful epidemiological, diagnostic and immunological evaluation of neonatal sepsis and the impact of gestational malaria have never been performed. A prospective longitudinal multicentre follow-up of 580 infants from birth to 3 months of age in urban and suburban Benin will be performed. At delivery, and every other week, all children will be examined and clinically evaluated for occurrence of sepsis. At delivery, cord blood systematic analysis of selected plasma and transcriptomic biomarkers (procalcitonin, interleukin (IL)-6, IL-10, IP10, Ethical approval has been obtained from the Comité d'Ethique de la Recherche - Institut des Sciences Biomédicales Appliquées (CER-ISBA 85 - 5 April 2016, extended on 3 February 2017). Results will be disseminated through international presentations at scientific meetings and publications in peer-reviewed journals. ClinicalTrials.gov registration number: NCT03780712.
Identifiants
pubmed: 32709653
pii: bmjopen-2020-036905
doi: 10.1136/bmjopen-2020-036905
pmc: PMC7380952
doi:
Substances chimiques
Biomarkers
0
Banques de données
ClinicalTrials.gov
['NCT03780712']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e036905Investigateurs
Aurax Fernando
(A)
Urbain Ahouayito
(U)
Basile Agossou
(B)
Caleb Ezinmegnon
(C)
Anauel Fortunato
(A)
Josué Fiagbenou
(J)
Djamirou Dossa
(D)
Dramane Abdou
(D)
Canisius Fantodji
(C)
Nawal Sare
(N)
Wilisto Bara
(W)
Razack Monde
(R)
Erasme Gbagidi
(E)
Larissa Allokpe
(L)
Armand Housemenou
(A)
Landry Assongba
(L)
Manfred Accrombessi
(M)
Florent Kouhouenou
(F)
Armand Hounsemenou
(A)
Amour Ridagba
(A)
Christiane Aguemon
(C)
Dissou Affolabi
(D)
Réné Perrin
(R)
Benjamin Hounkpatin
(B)
Dossou Dagba
(D)
Luis Augusto
(L)
Sophie Thibault
(S)
François Bartolo
(F)
Marine Mommert
(M)
Karen Brengel-Pesce
(K)
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: JYM, LV, JT, AP and SB are employed by an in vitro diagnostic company, bioMérieux SA. The remaining authors declare that this research was conducted in the absence of any commercial or financial relationship that could cause potential conflict of interest.
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