Long-lasting severe immune dysfunction in Ebola virus disease survivors.
Adult
Antibodies, Viral
/ blood
Antiviral Agents
/ pharmacology
B-Lymphocytes
/ immunology
Cytokines
/ blood
Ebolavirus
/ drug effects
Female
Genetic Markers
Hemorrhagic Fever, Ebola
/ complications
Humans
Immune System Diseases
/ complications
Immunoglobulin G
/ blood
Inflammation
/ genetics
Lymphocyte Activation
Male
Survivors
T-Lymphocytes
/ immunology
Transcriptome
Young Adult
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 07 2020
24 07 2020
Historique:
received:
05
09
2019
accepted:
29
06
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
9
9
2020
Statut:
epublish
Résumé
Long-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking. Here, we evaluate immune and gene expression profiles in 35 Guinean EBOV_S from the last West African outbreak, a median of 23 months (IQR [18-25]) after discharge from treatment center. Compared with healthy donors, EBOV_S exhibit increases of blood markers of inflammation, intestinal tissue damage, T cell and B cell activation and a depletion of circulating dendritic cells. All survivors have EBOV-specific IgG antibodies and robust and polyfunctional EBOV-specific memory T-cell responses. Deep sequencing of the genes expressed in blood reveals an enrichment in 'inflammation' and 'antiviral' pathways. Integrated analyses identify specific immune markers associated with the persistence of clinical symptoms. This study identifies a set of biological and genetic markers that could be used to define a signature of "chronic Ebola virus disease (CEVD)".
Identifiants
pubmed: 32709840
doi: 10.1038/s41467-020-17489-7
pii: 10.1038/s41467-020-17489-7
pmc: PMC7381622
doi:
Substances chimiques
Antibodies, Viral
0
Antiviral Agents
0
Cytokines
0
Genetic Markers
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3730Investigateurs
Ahidjo Ayouba
(A)
Eric Delaporte
(E)
Alpha Kabinet Keita
(AK)
Lamine Koivogui
(L)
Christine Lacabaratz
(C)
Claire Levy Marchal
(CL)
Yves Levy
(Y)
Hervé Raoul
(H)
Abdoulaye Touré
(A)
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