Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea.
age-related hearing loss
auditory brainstem responses
calcium channels
cochlea
exocytosis
inner hair cells
mouse
ribbon synapses
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
24
04
2020
accepted:
24
07
2020
pubmed:
28
7
2020
medline:
16
2
2021
entrez:
26
7
2020
Statut:
ppublish
Résumé
Age-related hearing loss (ARHL) is associated with the loss of inner hair cell (IHC) ribbon synapses, lower hearing sensitivity and decreased ability to understand speech, especially in a noisy environment. Little is known about the age-related physiological and morphological changes that occur at ribbon synapses. We show that the differing degrees of ARHL in four selected mouse stains is correlated with the loss of ribbon synapses, being most severe for the strains C57BL/6NTac and C57BL/6J, less so for C57BL/6NTac Mammalian cochlear inner hair cells (IHCs) are specialized sensory receptors able to provide dynamic coding of sound signals. This ability is largely conferred by their ribbon synapses, which tether a large number of vesicles at the IHC's presynaptic active zones, allowing high rates of sustained synaptic transmission onto the afferent fibres. How the physiological and morphological properties of ribbon synapses change with age remains largely unknown. Here, we have investigated the biophysical and morphological properties of IHC ribbon synapses in the ageing cochlea (9-12 kHz region) of four mouse strains commonly used in hearing research: early-onset progressive hearing loss (C57BL/6J and C57BL/6NTac) and 'good hearing' strains (C57BL/6NTac
Identifiants
pubmed: 32710572
doi: 10.1113/JP280018
pmc: PMC7612121
mid: EMS140587
doi:
Substances chimiques
Cadherins
0
Cdh23 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4339-4355Subventions
Organisme : Medical Research Council
ID : MR/S002510/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1503/2
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102892/Z/13/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC/UP/1503/2
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102892
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
Références
Ann Otol Rhinol Laryngol. 1993 Jan;102(1 Pt 2):1-16
pubmed: 8420477
Hear Res. 1996 Jul;96(1-2):41-5
pubmed: 8817305
Hear Res. 1990 Sep;48(1-2):79-91
pubmed: 2249962
Neuron. 2010 Nov 18;68(4):724-38
pubmed: 21092861
J Rehabil Res Dev. 2005 Jul-Aug;42(4 Suppl 2):9-24
pubmed: 16470462
Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5537-42
pubmed: 16567618
J Neurosci. 2010 Mar 24;30(12):4210-20
pubmed: 20335456
Cold Spring Harb Perspect Med. 2019 Aug 1;9(8):
pubmed: 30291149
Hear Res. 2015 Dec;330(Pt B):191-9
pubmed: 25769437
Electroencephalogr Clin Neurophysiol. 1982 Jun;53(6):612-20
pubmed: 6177506
J Neurophysiol. 2013 Aug;110(3):577-86
pubmed: 23596328
Hear Res. 1990 May;45(3):191-202
pubmed: 2358413
Lancet. 2005 Sep 24-30;366(9491):1111-20
pubmed: 16182900
Hear Res. 2008 Sep;243(1-2):87-94
pubmed: 18573325
Nature. 2007 Sep 6;449(7158):87-91
pubmed: 17805295
J Physiol. 2005 Feb 15;563(Pt 1):177-91
pubmed: 15613377
J Neurophysiol. 1996 Oct;76(4):2799-803
pubmed: 8899648
Front Neurosci. 2014 Oct 30;8:348
pubmed: 25400543
J Physiol. 2021 Jan;599(1):269-287
pubmed: 33179774
J Physiol. 2003 Apr 15;548(Pt 2):383-400
pubmed: 12588897
J Physiol. 2004 Jun 1;557(Pt 2):613-33
pubmed: 15064328
Hear Res. 1980 Jul;3(1):45-63
pubmed: 7400048
Nat Neurosci. 2002 Feb;5(2):147-54
pubmed: 11802170
Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16341-6
pubmed: 17911259
J Neurophysiol. 1984 Jun;51(6):1326-44
pubmed: 6737033
EMBO J. 2019 May 2;38(9):
pubmed: 30804003
Nat Neurosci. 2009 Apr;12(4):444-53
pubmed: 19270686
Hear Res. 2003 Sep;183(1-2):29-36
pubmed: 13679135
J Assoc Res Otolaryngol. 2014 Aug;15(4):571-83
pubmed: 24825663
J Neurosci. 1999 Jan 1;19(1):119-32
pubmed: 9870944
Nat Neurosci. 2010 Jan;13(1):45-52
pubmed: 20010821
J Physiol. 2020 Sep;598(18):3891-3910
pubmed: 32608086
J Neurosci. 2009 Nov 11;29(45):14077-85
pubmed: 19906956
J Physiol. 2020 Jan;598(1):151-170
pubmed: 31661723
J Neurosci. 2017 Mar 1;37(9):2471-2484
pubmed: 28154149
J Neurosci. 2013 Aug 21;33(34):13686-94
pubmed: 23966690
J Neurosci. 2011 Jan 19;31(3):801-8
pubmed: 21248103
J Acoust Soc Am. 1982 Nov;72(5):1441-9
pubmed: 7175031
Cold Spring Harb Perspect Med. 2019 Dec 2;9(12):
pubmed: 30617058
J Neurosci. 2011 Sep 21;31(38):13452-7
pubmed: 21940438
Annu Rev Physiol. 2011;73:311-34
pubmed: 21073336
Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):883-8
pubmed: 10639174
J Neurosci. 2008 Jul 23;28(30):7670-8
pubmed: 18650343
EMBO J. 2014 Feb 3;33(3):247-64
pubmed: 24442635
J Assoc Res Otolaryngol. 2001 Jun;2(2):118-29
pubmed: 11550522
Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6415-6424
pubmed: 30867284
J Comp Neurol. 1990 Nov 15;301(3):443-60
pubmed: 2262601
Cell. 2000 Jul 7;102(1):89-97
pubmed: 10929716
J Physiol. 2013 Aug 15;591(16):3811-20
pubmed: 23713031
Genome Med. 2016 Feb 15;8(1):16
pubmed: 26876963
Nat Commun. 2018 Oct 1;9(1):4015
pubmed: 30275467
Proc Natl Acad Sci U S A. 2013 May 21;110(21):8720-5
pubmed: 23650376
Nat Genet. 2003 Sep;35(1):21-3
pubmed: 12910270
J Assoc Res Otolaryngol. 2010 Dec;11(4):605-23
pubmed: 20706857
J Neurosci. 2015 Jul 1;35(26):9701-6
pubmed: 26134652
Ann Otol Rhinol Laryngol. 1974 May-Jun;83(3):294-303
pubmed: 4829736
J Acoust Soc Am. 1997 Jun;101(6):3546-53
pubmed: 9193043
Hear Res. 2006 Nov;221(1-2):104-18
pubmed: 17005343
J Acoust Soc Am. 1978 Feb;63(2):442-55
pubmed: 670542
J Neurosci Res. 2020 Sep;98(9):1745-1763
pubmed: 31762086
Curr Protoc Mouse Biol. 2011 Jun 01;1(2):279-87
pubmed: 26069055
J Neurosci. 2003 Nov 26;23(34):10832-40
pubmed: 14645476
Neuroscience. 2019 May 21;407:8-20
pubmed: 30099118
J Assoc Res Otolaryngol. 2016 Dec;17(6):493-523
pubmed: 27752925
Neurobiol Aging. 2012 Dec;33(12):2892-902
pubmed: 22405044
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4716-25
pubmed: 27462107
Science. 1982 Jun 11;216(4551):1239-41
pubmed: 7079757
Hear Res. 1997 Dec;114(1-2):83-92
pubmed: 9447922
Hear Res. 2012 Jan;283(1-2):80-8
pubmed: 22138310
J Comp Neurol. 1997 May 5;381(2):188-202
pubmed: 9130668
J Comp Neurol. 1996 Jul 22;371(2):208-21
pubmed: 8835727
Hear Res. 2005 Apr;202(1-2):63-73
pubmed: 15811700