miR-140 and miR-196a as Potential Biomarkers in Breast Cancer Patients.
Biomarkers
Quantitative PCR
breast cancer
miR-140
miR-196a
Journal
Asian Pacific journal of cancer prevention : APJCP
ISSN: 2476-762X
Titre abrégé: Asian Pac J Cancer Prev
Pays: Thailand
ID NLM: 101130625
Informations de publication
Date de publication:
01 Jul 2020
01 Jul 2020
Historique:
received:
07
10
2019
entrez:
27
7
2020
pubmed:
28
7
2020
medline:
7
4
2021
Statut:
epublish
Résumé
MiR-140 and miR-196a were known to be correlated with cancer diagnosis and prognosis. The current study aimed at the analysis of miR-140 and miR-196a expression patterns and their clinical significance for breast cancer (BC) patients. Differentially expressed miR-140 and miR-196a were examined via quantitative PCR in 110 cases of BC and their adjacent non-tumor (ANT) tissues. The results indicated that miR-140 and miR-196a, respectively, notably decreased and increased expression in BC samples in comparison with ANT (p<0.001). Reduced miR-140 expression was also related to Lymph node metastasis (LNM, P= 0.023) and stage (P = 0.009). Additionally, Receiver Operating Characteristics (ROC) analysis illustrated that miR-140 had a significant diagnostic accuracy for stage and LNM of BC patients. We also discovered a strong negative correlation between miR-196a expression with histological grade (P = 0.038), LNM (P = 0.012) and stage (P = 0.001). Overall, exploring the miR-140 and miR-196a profiles not only can statistically different among BC and ANT samples, but it is also expected to become potential BC biomarkers.<br />.
Identifiants
pubmed: 32711415
doi: 10.31557/APJCP.2020.21.7.1913
pmc: PMC7573432
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
MIRN196 microRNA, human
0
MicroRNAs
0
Mirn140 microRNA, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1913-1918Références
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