Anti-inflammatory and antiproliferative prenylated sulphur-containing amides from the leaves of Glycosmis pentaphylla.
Amides
/ isolation & purification
Animals
Anti-Inflammatory Agents
/ isolation & purification
Antineoplastic Agents, Phytogenic
/ isolation & purification
China
Hep G2 Cells
Humans
Mice
Molecular Structure
Nitric Oxide
/ metabolism
Phytochemicals
/ isolation & purification
Plant Leaves
/ chemistry
Prenylation
RAW 264.7 Cells
Rutaceae
/ chemistry
Sulfur
Anti-inflammatory property
Antiproliferative activity
Glycosmis pentaphylla
Rutaceae
Sulphur-containing amides
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
17
06
2020
revised:
20
07
2020
accepted:
20
07
2020
pubmed:
28
7
2020
medline:
16
3
2021
entrez:
27
7
2020
Statut:
ppublish
Résumé
Glycosmis pentaphylla (Retz.) DC (Rutaceae) has been traditionally considered as anti-cancer and anti-inflammatory medicine. However, active compounds of sulphur-containing amides remain largely unknown. In the present work, eighteen previously undescribed sulphur-containing amides (1-18) and three known analogues (19-21) were isolated from the leaves of G. pentaphylla. Their structures were elucidated by NMR spectroscopy and mass spectrometry. All isolated prenylated sulphur-containing amides were evaluated for their anti-inflammatory properties together with antiproliferative activities in vivo. Prenylated sulphur-containing amides exhibited significant inhibitory effects against nitric oxide (NO) production stimulated by lipopolysaccharide in mouse macrophage RAW 264.7 cells with the IC
Identifiants
pubmed: 32712133
pii: S0367-326X(20)30275-6
doi: 10.1016/j.fitote.2020.104693
pii:
doi:
Substances chimiques
Amides
0
Anti-Inflammatory Agents
0
Antineoplastic Agents, Phytogenic
0
Phytochemicals
0
Nitric Oxide
31C4KY9ESH
Sulfur
70FD1KFU70
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104693Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing financial interest.