Development of IglC and GroEL recombinant vaccines for francisellosis in Nile tilapia, Oreochromis niloticus.

Animals Bacterial Proteins / immunology Bacterial Vaccines / immunology Chaperonin 60 / immunology Cichlids / immunology Fish Diseases / immunology Francisella / immunology Gram-Negative Bacterial Infections / immunology Vaccines, Synthetic / immunology
Diatom-expressed IglC Francisella orientalis GroEL Immune response Montanide Nanoparticles

Journal

Fish & shellfish immunology
ISSN: 1095-9947
Titre abrégé: Fish Shellfish Immunol
Pays: England
ID NLM: 9505220

Informations de publication

Date de publication:
Oct 2020
Historique:
received: 29 04 2020
revised: 14 07 2020
accepted: 21 07 2020
pubmed: 28 7 2020
medline: 23 4 2021
entrez: 27 7 2020
Statut: ppublish

Résumé

Warm-water piscine francisellosis is a granulomatous bacterial disease caused by Francisella orientalis (Fo). The disease has been detected in a wide range of fish species globally, causing mortalities as high as 90% and significant economic losses. Currently there are no commercially available vaccines and few treatment options exist. In the current study, two novel recombinant vaccines were prepared using diatom-expressed IglC or bacterial-expressed GroEL proteins. The vaccine antigens were emulsified with either nanoparticles or a commercially available oil-based adjuvant. Nile tilapia, Oreochromis niloticus, fingerlings were immunized intracoelomically with the recombinant IglC or GroEL vaccines, diatoms alone or phosphate buffer saline. Approximately 840-degree days post-vaccination, fish were challenged via immersion with 10

Identifiants

DOI: 10.1016/j.fsi.2020.07.045 PMID: 32712230
pubmed: 32712230
pii: S1050-4648(20)30529-5
doi: 10.1016/j.fsi.2020.07.045
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Bacterial Vaccines 0
Chaperonin 60 0
Vaccines, Synthetic 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

341-349

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Khalid Shahin (K)

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, 95616, Davis, CA, USA.

Felipe Pirezan (F)

Department of Veterinary Clinics and Surgery, School of Veterinary Medicine, Federal University of Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil.

Matt Rogge (M)

Department of Biology, University of Wisconsin-Stevens Point, Stevens Point, WI, USA.

Benjamin R LaFrentz (BR)

USDA-ARS, Aquatic Animal Health Research Unit, Auburn, AL, USA.

Roshan P Shrestha (RP)

Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA.

Mark Hildebrand (M)

Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA.

Fangjia Lu (F)

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907, USA.

Harm HogenEsch (H)

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907, USA.

Esteban Soto (E)

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, 95616, Davis, CA, USA. Electronic address: sotomartinez@ucdavis.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Development of IglC and GroEL recombinant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Development of IglC and GroEL recombinant...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antibactériens › Development of IglC and GroEL recombinant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Chaperons moléculaires › Protéines du choc thermique › Chaperonines › Chaperonines du groupe I › Chaperonine-60 › Development of IglC and GroEL recombinant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Perciformes › Cichlides › Development of IglC and GroEL recombinant...
questionsmedicales.fr › Maladies de l'animal › Maladies des poissons › Development of IglC and GroEL recombinant...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Francisella › Development of IglC and GroEL recombinant...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Development of IglC and GroEL recombinant...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Vaccins synthétiques › Development of IglC and GroEL recombinant...