Characterization of
Adjuvants, Immunologic
/ administration & dosage
Administration, Intranasal
Animals
Anthrax
/ prevention & control
Anthrax Vaccines
/ administration & dosage
Antibodies, Bacterial
/ immunology
Bacillus anthracis
/ immunology
Female
Lipid A
/ administration & dosage
Mice
Mice, Inbred BALB C
Nanoparticles
Spores, Bacterial
/ immunology
Vaccines, Subunit
/ immunology
anthrax
monophosphoryl lipid A (MPLA)
nanolipoprotein particle (NLP)
nanoscaffold
spore antigens
vaccine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
02
2020
accepted:
19
05
2020
entrez:
28
7
2020
pubmed:
28
7
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Subunit vaccines are theoretically safe and easy to manufacture but require effective adjuvants and delivery systems to yield protective immunity, particularly at critical mucosal sites such as the lung. We investigated nanolipoprotein particles (NLPs) containing the Toll-like receptor 4 agonist monophosphoryl lipid A (MPLA) as a platform for intranasal vaccination against
Identifiants
pubmed: 32714323
doi: 10.3389/fimmu.2020.01264
pmc: PMC7344197
doi:
Substances chimiques
Adjuvants, Immunologic
0
Anthrax Vaccines
0
Antibodies, Bacterial
0
Lipid A
0
Vaccines, Subunit
0
monophosphoryl lipid A
MWC0ET1L2P
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1264Subventions
Organisme : NIAID NIH HHS
ID : R01 AI093493
Pays : United States
Informations de copyright
Copyright © 2020 Weilhammer, Dunkle, Boone, Gilmore, Khemmani, Peters, Hoeprich, Fischer, Blanchette, Driks and Rasley.
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