Gray matter alteration in heroin-dependent men: An atlas-based magnetic resonance imaging study.
Gray matter
Heroin addiction
Large deformation diffeomorphic metric mapping
Magnetic resonance imaging
Journal
Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001
Informations de publication
Date de publication:
30 10 2020
30 10 2020
Historique:
received:
03
04
2020
revised:
18
07
2020
accepted:
20
07
2020
pubmed:
28
7
2020
medline:
5
1
2021
entrez:
28
7
2020
Statut:
ppublish
Résumé
Previous imaging studies on heroin addiction have reported brain morphological alterations. However, the effects of heroin exposure on gray matter volume varied among different studies due to different factors such as substitution treatment or mandatory abstinence. Meanwhile, the relationship between gray matter and heroin use history remains unknown. Thirty-three male heroin-dependent (HD) individuals who are not under any substitution treatment or mandatory abstinence and 40 male healthy controls (HC) were included in this structural magnetic resonance imaging study. With an atlas-based approach, gray matter structures up to individual functional area were delineated, and the differences in their volumes between the HD and HC groups were analyzed. In addition, the relationship between gray matter volume and duration of heroin use was explored. The HD group demonstrated significantly lower cortical volume mainly in the prefrontal cortex and mesolimbic dopaminergic regions across different parcellation levels, whereas several visual and somatosensory cortical regions in the HD group had greater volume relative to the HC group at a more detailed parcellation level. The duration of heroin use was negatively correlated with the gray matter volume of prefrontal cortex. These findings suggest that heroin addiction be related to gray matter alteration and might be related to damage/maladaption of the inhibitory control, reward, visual, and somatosensory functions of the brain, although cognitive correlates are warranted in future study. In addition, the atlas-based morphology analysis is a potential tool to help researchers search biomarkers of heroin addiction.
Identifiants
pubmed: 32717665
pii: S0925-4927(20)30122-0
doi: 10.1016/j.pscychresns.2020.111150
pmc: PMC8170872
mid: NIHMS1707477
pii:
doi:
Substances chimiques
Heroin
70D95007SX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111150Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB017183
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None declared.
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