Probing 2-acetylbenzofuran hydrazones and their metal complexes as α-glucosidase inhibitors.
Acetylbenzofuran
Hydrazones
Metal complexes
α-glucosidase inhibitors
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
27
01
2020
revised:
04
07
2020
accepted:
06
07
2020
pubmed:
28
7
2020
medline:
3
3
2021
entrez:
28
7
2020
Statut:
ppublish
Résumé
Inhibition of α-glucosidase is one of the important approaches in designing antidiabetic drugs for its role in decrease of the carbohydrates digestion to avoid post-prandial increase in blood sugar levels in diabetic patients. In the present study we designed a novel series of 2-acetylbenzofuran hydrazones (L1-L7) and their metal (II) complexes Cu (II), Co (II), Zn (II) and Mn (II) (8-29) and screened for inhibitory activity against the yeast α-glucosidase. The synthesis of hydrazones incorporated the use of I
Identifiants
pubmed: 32717690
pii: S0045-2068(20)31379-1
doi: 10.1016/j.bioorg.2020.104082
pii:
doi:
Substances chimiques
Benzofurans
0
Coordination Complexes
0
Glycoside Hydrolase Inhibitors
0
Hydrazones
0
Metals, Heavy
0
2-acetylbenzofuran
A1FJQ7D0K3
alpha-Glucosidases
EC 3.2.1.20
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104082Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have declared no conflict of interest.