From the sea to the bee: Gellan gum-honey-diatom composite to deliver resveratrol for cartilage regeneration under oxidative stress conditions.
Animals
Antioxidants
/ administration & dosage
Bees
/ physiology
Biocompatible Materials
/ chemistry
Cartilage, Articular
/ physiology
Cell Survival
/ drug effects
Cells, Cultured
Chondrogenesis
/ drug effects
Diatoms
Drug Liberation
Honey
Humans
Mesenchymal Stem Cells
Oxidative Stress
/ drug effects
Polysaccharides, Bacterial
/ chemistry
Porosity
Regeneration
/ drug effects
Resveratrol
/ administration & dosage
Staphylococcus aureus
/ drug effects
Tissue Engineering
/ methods
Tissue Scaffolds
/ chemistry
Antioxidant
Cartilage regeneration
Composite
Diatoms
Gellan gum
Resveratrol
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
01 Oct 2020
01 Oct 2020
Historique:
received:
27
02
2020
revised:
03
05
2020
accepted:
03
05
2020
entrez:
29
7
2020
pubmed:
29
7
2020
medline:
15
4
2021
Statut:
ppublish
Résumé
Carbohydrate-based porous scaffolds are promising biomaterials to support cartilage regeneration. In this respect, their composition could be designed to face clinical challenges, i.e., articular load bearing, infections and oxidative stress. Herein, an innovative scaffold has been developed, combining raw materials belonging to different kingdoms of life. Indeed, gellan gum, a bacterial-derived carbohydrate, was blended with a beehive product (Manuka honey) with prominent antibacterial features. Moreover, resveratrol, a phytoalexin with powerful antioxidant activity, was loaded into the silica shells of diatoms, unicellular microalgae with cytocompatible features. The developed composite porous scaffolds demonstrated mechanical properties suitable for cartilage regeneration. Furthermore, they allowed the controlled release of resveratrol, hindering bacterial proliferation and oxidative stress damage, while supporting stem cell colonization and chondrogenic differentiation.
Identifiants
pubmed: 32718592
pii: S0144-8617(20)30584-1
doi: 10.1016/j.carbpol.2020.116410
pii:
doi:
Substances chimiques
Antioxidants
0
Biocompatible Materials
0
Polysaccharides, Bacterial
0
gellan gum
7593U09I4D
Resveratrol
Q369O8926L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116410Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.