Neurochemistry of hyponatremic encephalopathy evaluated by MR spectroscopy.
Aspartic Acid
/ analogs & derivatives
Child
Creatine
/ analysis
Glutamic Acid
/ analysis
Glutamine
/ analysis
Hepatic Encephalopathy
/ diagnosis
Humans
Hyponatremia
/ diagnosis
Inositol
/ analysis
Magnetic Resonance Spectroscopy
/ methods
Male
Neurochemistry
/ methods
Phosphocreatine
/ analysis
Sodium
/ analysis
Excitotoxicity
Glutamate
Glutamine
Hyponatremia
MR spectroscopy
Journal
Brain & development
ISSN: 1872-7131
Titre abrégé: Brain Dev
Pays: Netherlands
ID NLM: 7909235
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
29
03
2020
revised:
06
07
2020
accepted:
07
07
2020
pubmed:
29
7
2020
medline:
3
7
2021
entrez:
29
7
2020
Statut:
ppublish
Résumé
MR spectroscopy in a patient with hyponatremic encephalopathy due to the syndrome of inappropriate secretion of antidiuretic hormone revealed decreased N-acetyl-aspartate, creatine plus phosphocreatine, choline-containing compounds, and myo-inositol, with normal glutamate and increased glutamine, which normalized after Na normalization. The decreased concentrations of creatine plus phosphocreatine, choline-containing compounds and myo-inositol are explained by their release as osmolytes from brain cells to adapt to hypo-osmolality induced cerebral edema. Increased glutamine, which not only acts as an osmolyte but also protects neurons under excitotoxic conditions, may suggest that a disrupted glutamate-glutamine cycle may play an important role in the pathogenesis of hyponatremic encephalopathy.
Identifiants
pubmed: 32718672
pii: S0387-7604(20)30188-1
doi: 10.1016/j.braindev.2020.07.005
pii:
doi:
Substances chimiques
Phosphocreatine
020IUV4N33
Glutamine
0RH81L854J
Aspartic Acid
30KYC7MIAI
Glutamic Acid
3KX376GY7L
Inositol
4L6452S749
N-acetylaspartate
997-55-7
Sodium
9NEZ333N27
Creatine
MU72812GK0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
767-770Informations de copyright
Copyright © 2020 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.