Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
10
01
2019
accepted:
18
06
2020
pubmed:
29
7
2020
medline:
1
12
2020
entrez:
29
7
2020
Statut:
ppublish
Résumé
Oxytocin (OT) is a great facilitator of social life but, although its effects on socially relevant brain regions have been extensively studied, OT neuron activity during actual social interactions remains unexplored. Most OT neurons are magnocellular neurons, which simultaneously project to the pituitary and forebrain regions involved in social behaviors. In the present study, we show that a much smaller population of OT neurons, parvocellular neurons that do not project to the pituitary but synapse onto magnocellular neurons, is preferentially activated by somatosensory stimuli. This activation is transmitted to the larger population of magnocellular neurons, which consequently show coordinated increases in their activity during social interactions between virgin female rats. Selectively activating these parvocellular neurons promotes social motivation, whereas inhibiting them reduces social interactions. Thus, parvocellular OT neurons receive particular inputs to control social behavior by coordinating the responses of the much larger population of magnocellular OT neurons.
Identifiants
pubmed: 32719563
doi: 10.1038/s41593-020-0674-y
pii: 10.1038/s41593-020-0674-y
doi:
Substances chimiques
Oxytocin
50-56-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1125-1137Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S000224/1
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS094640
Pays : United States
Commentaires et corrections
Type : CommentIn
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