rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461.
CX-5461
DNA damage response
RNA polymerase I
ovarian cancer
rDNA copy number
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
12
2019
accepted:
15
06
2020
entrez:
29
7
2020
pubmed:
29
7
2020
medline:
29
7
2020
Statut:
epublish
Résumé
Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and proliferation and a consistent feature of cancer cells. We have demonstrated that inhibition of rDNA transcription by the Pol I transcription inhibitor CX-5461 selectively kills tumor cells
Identifiants
pubmed: 32719798
doi: 10.3389/fcell.2020.00568
pmc: PMC7349920
doi:
Types de publication
Journal Article
Langues
eng
Pagination
568Informations de copyright
Copyright © 2020 Son, Hannan, Poortinga, Hein, Cameron, Ganley, Sheppard, Pearson, Hannan and Sanij.
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