Gretchen Poortinga

Affiliations

Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.
Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Parkville, VIC, Australia.

Publications (8)

rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461.

Frontiers in cell and developmental biology

Avec: Jinbae Son , Katherine M Hannan , Gretchen Poortinga , Nadine Hein , Donald P Cameron , Austen R D Ganley , Karen E Sheppard , Richard B Pearson , Ross D Hannan , Elaine Sanij

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.

Cancer discovery

Avec: Amit Khot , Natalie Brajanovski , Donald P Cameron , Nadine Hein , Kylee H Maclachlan , Elaine Sanij , John Lim , John Soong , Emma Link , Piers Blombery , Ella R Thompson , Andrew Fellowes , Karen E Sheppard , Grant A McArthur , Richard B Pearson , Ross D Hannan , Gretchen Poortinga , Simon J Harrison

CX-5461 Preferentially Induces Top2α-Dependent DNA Breaks at Ribosomal DNA Loci.

Biomedicines

Avec: Donald P Cameron , Jirawas Sornkom , Sameerh Alsahafi , Denis Drygin , Gretchen Poortinga , Grant A McArthur , Nadine Hein , Ross Hannan , Konstantin I Panov

Targeting the ribosome to treat multiple myeloma.

Molecular therapy. Oncology

Avec: Kylee H Maclachlan , Kezia Gitareja , Jian Kang , Andrew Cuddihy , Yuxi Cao , Nadine Hein , Carleen Cullinane , Ching-Seng Ang , Natalie Brajanovski , Richard B Pearson , Amit Khot , Elaine Sanij , Ross D Hannan , Gretchen Poortinga , Simon J Harrison

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.

Nature communications

Avec: Elaine Sanij , Katherine M Hannan , Jiachen Xuan , Shunfei Yan , Jessica E Ahern , Anna S Trigos , Natalie Brajanovski , Jinbae Son , Keefe T Chan , Olga Kondrashova , Elizabeth Lieschke , Matthew J Wakefield , Daniel Frank , Sarah Ellis , Carleen Cullinane , Jian Kang , Gretchen Poortinga , Purba Nag , Andrew J Deans , Kum Kum Khanna , Linda Mileshkin , Grant A McArthur , John Soong , Els M J J Berns , Ross D Hannan , Clare L Scott , Karen E Sheppard , Richard B Pearson

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Shatha AbuHammad , Carleen Cullinane , Claire Martin , Zoe Bacolas , Teresa Ward , Huiqin Chen , Alison Slater , Kerry Ardley , Laura Kirby , Keefe T Chan , Natalie Brajanovski , Lorey K Smith , Aparna D Rao , Emily J Lelliott , Margarete Kleinschmidt , Ismael A Vergara , Anthony T Papenfuss , Peter Lau , Prerana Ghosh , Sue Haupt , Ygal Haupt , Elaine Sanij , Gretchen Poortinga , Richard B Pearson , Hendrik Falk , David J Curtis , Paul Stupple , Mark Devlin , Ian Street , Michael A Davies , Grant A McArthur , Karen E Sheppard

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.

Communications biology

Avec: Jeannine Diesch , Megan J Bywater , Elaine Sanij , Donald P Cameron , William Schierding , Natalie Brajanovski , Jinbae Son , Jirawas Sornkom , Nadine Hein , Maurits Evers , Richard B Pearson , Grant A McArthur , Austen R D Ganley , Justin M O'Sullivan , Ross D Hannan , Gretchen Poortinga

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.

The EMBO journal

Avec: Eric P Kusnadi , Anna S Trigos , Carleen Cullinane , David L Goode , Ola Larsson , Jennifer R Devlin , Keefe T Chan , David P De Souza , Malcolm J McConville , Grant A McArthur , George Thomas , Elaine Sanij , Gretchen Poortinga , Ross D Hannan , Katherine M Hannan , Jian Kang , Richard B Pearson

Réseau de co-auteurs

Richard B Pearson 7 collaborations

Elaine Sanij 7 collaborations

Ross D Hannan 6 collaborations

Grant A McArthur 6 collaborations

Nadine Hein 5 collaborations

Natalie Brajanovski 5 collaborations

Donald P Cameron 4 collaborations

Karen E Sheppard 4 collaborations

Carleen Cullinane 4 collaborations

Jinbae Son 3 collaborations

Katherine M Hannan 3 collaborations

Jian Kang 3 collaborations

Keefe T Chan 3 collaborations

Austen R D Ganley 2 collaborations

Amit Khot 2 collaborations

Kylee H Maclachlan 2 collaborations

John Soong 2 collaborations

Simon J Harrison 2 collaborations

Jirawas Sornkom 2 collaborations

Anna S Trigos 2 collaborations

John Lim 1 collaboration

Emma Link 1 collaboration

Piers Blombery 1 collaboration

Ella R Thompson 1 collaboration

Andrew Fellowes 1 collaboration

Sameerh Alsahafi 1 collaboration

Denis Drygin 1 collaboration

Ross Hannan 1 collaboration

Konstantin I Panov 1 collaboration

Kezia Gitareja 1 collaboration

Andrew Cuddihy 1 collaboration

Yuxi Cao 1 collaboration

Ching-Seng Ang 1 collaboration

Jiachen Xuan 1 collaboration

Shunfei Yan 1 collaboration

Jessica E Ahern 1 collaboration

Olga Kondrashova 1 collaboration

Elizabeth Lieschke 1 collaboration

Matthew J Wakefield 1 collaboration

Daniel Frank 1 collaboration

Sarah Ellis 1 collaboration

Purba Nag 1 collaboration

Andrew J Deans 1 collaboration

Kum Kum Khanna 1 collaboration

Linda Mileshkin 1 collaboration

Els M J J Berns 1 collaboration

Clare L Scott 1 collaboration

Shatha AbuHammad 1 collaboration

Claire Martin 1 collaboration

Zoe Bacolas 1 collaboration

Teresa Ward 1 collaboration

Huiqin Chen 1 collaboration

Alison Slater 1 collaboration

Kerry Ardley 1 collaboration

Laura Kirby 1 collaboration

Lorey K Smith 1 collaboration

Aparna D Rao 1 collaboration

Emily J Lelliott 1 collaboration

Margarete Kleinschmidt 1 collaboration

Ismael A Vergara 1 collaboration

Anthony T Papenfuss 1 collaboration

Peter Lau 1 collaboration

Prerana Ghosh 1 collaboration

Sue Haupt 1 collaboration

Ygal Haupt 1 collaboration

Hendrik Falk 1 collaboration

David J Curtis 1 collaboration

Paul Stupple 1 collaboration

Mark Devlin 1 collaboration

Ian Street 1 collaboration

Michael A Davies 1 collaboration

Jeannine Diesch 1 collaboration

Megan J Bywater 1 collaboration

William Schierding 1 collaboration

Maurits Evers 1 collaboration

Justin M O'Sullivan 1 collaboration

Eric P Kusnadi 1 collaboration

David L Goode 1 collaboration

Ola Larsson 1 collaboration

Jennifer R Devlin 1 collaboration

David P De Souza 1 collaboration

Malcolm J McConville 1 collaboration

George Thomas 1 collaboration