Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics.
Allosteric Regulation
Binding Sites
Drug Design
Fibroblast Growth Factors
/ chemistry
HEK293 Cells
Humans
Hydrophobic and Hydrophilic Interactions
Models, Molecular
Molecular Docking Simulation
Molecular Structure
NAV1.6 Voltage-Gated Sodium Channel
/ chemistry
Peptidomimetics
/ chemical synthesis
Protein Binding
/ drug effects
Protein Structure, Secondary
fibroblast growth factor 14 (FGF14)
molecular docking
neurotherapeutics
peptidomimetics
protein:protein interactions (PPIs)
voltage-gated Na+ (Nav) channels
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
24 Jul 2020
24 Jul 2020
Historique:
received:
21
06
2020
revised:
14
07
2020
accepted:
22
07
2020
entrez:
30
7
2020
pubmed:
30
7
2020
medline:
2
3
2021
Statut:
epublish
Résumé
Disruption of protein:protein interactions (PPIs) that regulate the function of voltage-gated Na
Identifiants
pubmed: 32722255
pii: molecules25153365
doi: 10.3390/molecules25153365
pmc: PMC7435778
pii:
doi:
Substances chimiques
NAV1.6 Voltage-Gated Sodium Channel
0
Peptidomimetics
0
SCN8A protein, human
0
fibroblast growth factor 14
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01MH124351
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008280
Pays : United States
Organisme : NIA NIH HHS
ID : T32AG051131
Pays : United States
Organisme : NIH HHS
ID : R01MH095995
Pays : United States
Organisme : NIDA NIH HHS
ID : U18 DA052504
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH124351
Pays : United States
Organisme : NIH HHS
ID : S10OD023576
Pays : United States
Organisme : NIH HHS
ID : S10 OD023576
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111107
Pays : United States
Organisme : NIH HHS
ID : P30DA028821
Pays : United States
Organisme : NIH HHS
ID : R01MH111107
Pays : United States
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