The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients.
Y-chromosome
allograft
immunogenicity
pluripotent stem cells
stem cell therapeutics
Journal
Stem cells and development
ISSN: 1557-8534
Titre abrégé: Stem Cells Dev
Pays: United States
ID NLM: 101197107
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
pubmed:
30
7
2020
medline:
3
9
2021
entrez:
30
7
2020
Statut:
ppublish
Résumé
Pluripotent stem cells are promising candidates for cell-based regenerative therapies. To avoid rejection of transplanted cells, several approaches are being pursued to reduce immunogenicity of the cells or modulate the recipient's immune response. These include gene editing to reduce the antigenicity of cell products, immunosuppression of the host, or using major histocompatibility complex-matched cells from cell banks. In this context, we have investigated the antigenicity of H-Y antigens, a class of minor histocompatibility antigens encoded by the Y chromosome, to assess whether the gender of the donor affects the cell's antigenicity. In a murine transplant model, we show that the H-Y antigen in undifferentiated embryonic stem cells (ESCs), as well as ESC-derived endothelial cells, provokes T- and B cell responses in female recipients.
Identifiants
pubmed: 32723003
doi: 10.1089/scd.2019.0299
pmc: PMC7482111
doi:
Substances chimiques
H-Y Antigen
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1179-1189Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL140236
Pays : United States
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