Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus.
Benin
Lassa fever
Lassa virus
genome
new lineage
outbreak
phylogeny
serology
Journal
Emerging microbes & infections
ISSN: 2222-1751
Titre abrégé: Emerg Microbes Infect
Pays: United States
ID NLM: 101594885
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
pubmed:
30
7
2020
medline:
13
4
2021
entrez:
30
7
2020
Statut:
ppublish
Résumé
We report two outbreaks of Lassa fever that occurred in Benin in 2014 and 2016 with 20 confirmed cases and 50% (10/20) mortality. Benin was not previously considered to be an endemic country for Lassa fever, resulting in a delay to diagnose the disease and its human transmission. Molecular investigations showed the viral genomes to be similar to that of the Togo strain, which is genetically very different from other known strains and confirms the existence of a new lineage. Endemic circulation of Lassa virus in a new territory and the genetic diversity thus confirm that this virus represents a growing threat for West African people. Given the divergence of the Benin strain from the prototypic Josiah Sierra Leone strain frequently used to generate vaccine candidates, the efficacy of vaccine candidates should also be demonstrated with this strain.
Identifiants
pubmed: 32723007
doi: 10.1080/22221751.2020.1796528
pmc: PMC7473144
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Immunoglobulin M
0
RNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1761-1770Subventions
Organisme : World Health Organization
ID : 001
Pays : International
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