A meta-analysis of the local application of vancomycin powder to prevent surgical site infection after spinal surgeries.
Spinal surgery
antibiotics
clinical practice
meta-analysis
surgical site infection
vancomycin powder
Journal
The Journal of international medical research
ISSN: 1473-2300
Titre abrégé: J Int Med Res
Pays: England
ID NLM: 0346411
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
entrez:
30
7
2020
pubmed:
30
7
2020
medline:
15
5
2021
Statut:
ppublish
Résumé
This study aimed to systematically analyze the effectiveness and safety of the local application of vancomycin powder to prevent surgical site infection (SSI) after spinal surgeries and provide guidance for clinical practice. Two researchers independently searched PubMed, Web of Science, Elsevier, and China National Knowledge Infrastructure using the MeSH terms "spinal surgery," "vancomycin," "local," "topical," "prophylactic," "surgical site infection," and "SSI" to identify studies published between January 2010 and January 2020 on the local application of vancomycin powder for preventing SSI after spinal surgeries. The outcome assessment indicators were analyzed using RevMan 5.3 software. Three randomized controlled trials, two prospective studies, and 26 retrospective studies were included in the current research. The results of the meta-analysis revealed significant differences between the vancomycin and control groups (non-vancomycin group) concerning the incidence of SSI (risk ratio = 0.39, 95% confidence interval = 0.28-0.55, Local application of vancomycin powder is an effective and safe method to prevent SSI after spinal surgeries.
Identifiants
pubmed: 32723127
doi: 10.1177/0300060520920057
pmc: PMC7391445
doi:
Substances chimiques
Anti-Bacterial Agents
0
Powders
0
Vancomycin
6Q205EH1VU
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
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