Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin.

Animals Brain / metabolism Cattle Encephalopathy, Bovine Spongiform / prevention & control Heparin Prion Proteins Prions / metabolism Swine
bovine heparin bovine spongiform encephalopathy heparin porcine heparin prion protein prions

Journal

Emerging infectious diseases
ISSN: 1080-6059
Titre abrégé: Emerg Infect Dis
Pays: United States
ID NLM: 9508155

Informations de publication

Date de publication:
10 2020
Historique:
pubmed: 30 7 2020
medline: 22 6 2021
entrez: 30 7 2020
Statut: ppublish

Résumé

US manufacturers, concerned about bovine spongiform encephalopathy (BSE), ceased marketing bovine heparin in the 1990s. Recent short supplies of safe porcine heparin suggest that reintroducing bovine heparin might benefit public health. We purified heparin from crude bovine extract spiked with BSE agent, removing substantial infectivity and abnormal prion proteins (PrP

Identifiants

DOI: 10.3201/eid2610.200142 PMID: 32723431 PMC: PMC7510749
pubmed: 32723431
doi: 10.3201/eid2610.200142
pmc: PMC7510749
doi:

Substances chimiques

Prion Proteins 0
Prions 0
Heparin 9005-49-6

Types de publication

Journal Article Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2478-2480

Références

J Gen Virol. 2018 Mar;99(3):422-433
pubmed: 29458529
Pharmacoepidemiol Drug Saf. 2020 May;29(5):575-581
pubmed: 32134162
Arch Virol. 2003 Apr;148(4):677-91
pubmed: 12664293
PLoS One. 2011 Mar 11;6(3):e17633
pubmed: 21412419
AAPS J. 2017 May;19(3):765-771
pubmed: 28116677
PLoS Pathog. 2015 Jun 18;11(6):e1004983
pubmed: 26086786
Lancet. 1996 Apr 6;347(9006):921-5
pubmed: 8598754

Auteurs

Cyrus Bett (C)

Omozusi Andrews (O)

David M Asher (DM)

Teresa Pilant (T)

David Keire (D)

Luisa Gregori (L)

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Eliminating Spiked Bovine Spongiform...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Eliminating Spiked Bovine Spongiform...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Eliminating Spiked Bovine Spongiform...
questionsmedicales.fr › Maladies de l'animal › Maladies des bovins › Encéphalopathie spongiforme bovine › Eliminating Spiked Bovine Spongiform...
questionsmedicales.fr › Glucides › Polyosides › Glycosaminoglycanes › Héparine › Eliminating Spiked Bovine Spongiform...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Prions › Protéines prion › Eliminating Spiked Bovine Spongiform...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Prions › Eliminating Spiked Bovine Spongiform...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Eliminating Spiked Bovine Spongiform...