CHOP and c-JUN up-regulate the mutant Z α
Alleles
Animals
Endoplasmic Reticulum Stress
/ genetics
Humans
Liver
/ metabolism
Liver Diseases
/ genetics
Mice
Mice, Knockout
Mutation
Protein Aggregation, Pathological
/ genetics
Protein Folding
Proto-Oncogene Proteins c-jun
/ genetics
Transcription Factor CHOP
/ genetics
Transcription, Genetic
Up-Regulation
alpha 1-Antitrypsin
/ biosynthesis
CHOP
SERPINA1
alpha1-antitrypsin
alpha1-antitrypsin deficiency
c-JUN
c-Jun transcription factor
liver
liver injury
serpin
transcription regulation
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
18 09 2020
18 09 2020
Historique:
received:
10
05
2020
revised:
23
07
2020
pubmed:
30
7
2020
medline:
27
1
2021
entrez:
30
7
2020
Statut:
ppublish
Résumé
α
Identifiants
pubmed: 32723872
pii: S0021-9258(17)50038-1
doi: 10.1074/jbc.RA120.014307
pmc: PMC7504927
pii:
doi:
Substances chimiques
DDIT3 protein, human
0
Ddit3 protein, mouse
0
Proto-Oncogene Proteins c-jun
0
SERPINA1 protein, human
0
Serpina1a protein, mouse
0
alpha 1-Antitrypsin
0
Transcription Factor CHOP
147336-12-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13213-13223Informations de copyright
© 2020 Attanasio et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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