Polyphosphate Functions
chelator
cisplatin
iron regulation
oxidative damage
polyphosphate
stress response
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
28 07 2020
28 07 2020
Historique:
entrez:
30
7
2020
pubmed:
30
7
2020
medline:
13
7
2021
Statut:
epublish
Résumé
Maintaining cellular iron homeostasis is critical for organismal survival. Whereas iron depletion negatively affects the many metabolic pathways that depend on the activity of iron-containing enzymes, any excess of iron can cause the rapid formation of highly toxic reactive oxygen species (ROS) through Fenton chemistry. Although several cellular iron chelators have been identified, little is known about if and how organisms can prevent the Fenton reaction. By studying the effects of cisplatin, a commonly used anticancer drug and effective antimicrobial, we discovered that cisplatin elicits severe iron stress and oxidative DNA damage in bacteria. We found that both of these effects are successfully prevented by polyphosphate (polyP), an abundant polymer consisting solely of covalently linked inorganic phosphates. Subsequent
Identifiants
pubmed: 32723918
pii: mBio.01017-20
doi: 10.1128/mBio.01017-20
pmc: PMC7387796
pii:
doi:
Substances chimiques
Fenton's reagent
0
Iron Chelating Agents
0
Polyphosphates
0
Reactive Oxygen Species
0
Hydrogen Peroxide
BBX060AN9V
Iron
E1UOL152H7
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : T32 AG000114
Pays : United States
Informations de copyright
Copyright © 2020 Beaufay et al.
Références
J Bacteriol. 1995 May;177(9):2305-14
pubmed: 7730258
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11210-5
pubmed: 9326588
Mol Pharmacol. 2002 Nov;62(5):1154-9
pubmed: 12391279
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14391-5
pubmed: 8962061
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5
pubmed: 10829079
Ann N Y Acad Sci. 1997 Nov 21;829:242-9
pubmed: 9472324
Blood. 2012 Jun 21;119(25):5972-9
pubmed: 22517894
J Inorg Biochem. 2011 May;105(5):669-74
pubmed: 21450270
Eur J Cancer. 2000 Oct;36(15):1984-90
pubmed: 11000581
Mol Cell. 2014 Mar 6;53(5):689-99
pubmed: 24560923
Biochem J. 1993 Sep 15;294 ( Pt 3):929-34
pubmed: 8379947
PLoS One. 2013 Jun 03;8(6):e66220
pubmed: 23755301
Analyst. 2014 Dec 7;139(23):6284-9
pubmed: 25315398
Nat Commun. 2014 Sep 15;5:4910
pubmed: 25222563
J Bacteriol. 2018 Feb 23;200(6):
pubmed: 29311274
Free Radic Biol Med. 2001 Dec 1;31(11):1352-9
pubmed: 11728806
J Inorg Biochem. 2002 Jul 25;91(1):306-11
pubmed: 12121789
Mol Microbiol. 2004 May;52(3):861-72
pubmed: 15101990
J Bacteriol. 1996 Mar;178(5):1394-400
pubmed: 8631717
Cell. 2001 Mar 23;104(6):901-12
pubmed: 11290327
Mini Rev Med Chem. 2011 Mar;11(3):214-24
pubmed: 21534930
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
J Biol Inorg Chem. 2006 Nov;11(8):1063-74
pubmed: 16896806
Pharmacol Ther. 1987;34(2):155-66
pubmed: 3317449
Int J Med Microbiol. 2001 May;291(2):67-79
pubmed: 11437341
Inorg Chem. 2004 Feb 9;43(3):1190-6
pubmed: 14753844
Nat Chem Biol. 2014 Jan;10(1):9-17
pubmed: 24346035
Environ Microbiol. 2011 Sep;13(9):2587-99
pubmed: 21854518
J Biol Chem. 2003 Mar 14;278(11):9100-6
pubmed: 12509415
Annu Rev Biochem. 2009;78:605-47
pubmed: 19344251
Biometals. 2018 Oct;31(5):681-704
pubmed: 30014354
Genetics. 2001 May;158(1):41-64
pubmed: 11333217
PLoS Genet. 2013;9(9):e1003810
pubmed: 24068972
J Biol Chem. 1993 Sep 25;268(27):20116-25
pubmed: 8376370
Science. 1988 Sep 30;241(4874):1813-5
pubmed: 3175622
Front Oncol. 2019 Dec 12;9:1410
pubmed: 31921667
Radiat Res. 1997 Aug;148(2):181-7
pubmed: 9254738
Nature. 1965 Feb 13;205:698-9
pubmed: 14287410
Mol Cell. 2016 Sep 1;63(5):768-80
pubmed: 27570072
FEMS Microbiol Rev. 2003 Jun;27(2-3):215-37
pubmed: 12829269
Nat Rev Cancer. 2007 Aug;7(8):573-84
pubmed: 17625587
Biochemistry. 2007 Feb 6;46(5):1329-42
pubmed: 17260962
Curr Opin Microbiol. 2015 Apr;24:1-6
pubmed: 25589044
Nat Rev Microbiol. 2005 Mar;3(3):251-61
pubmed: 15738951
Microbiol Mol Biol Rev. 2008 Sep;72(3):545-54
pubmed: 18772288
BMC Biotechnol. 2011 Aug 12;11:82
pubmed: 21838857
Clin Cancer Res. 2006 Oct 1;12(19):5817-25
pubmed: 17020989
J Bacteriol. 2013 Sep;195(17):3940-6
pubmed: 23813732
Arch Toxicol. 2007 Jul;81(7):495-504
pubmed: 17216432
Bioinorg Chem Appl. 2005;:179-90
pubmed: 18365098
J Biol Chem. 1991 Jan 25;266(3):1478-83
pubmed: 1846355
Cell Chem Biol. 2019 Jan 17;26(1):85-97.e4
pubmed: 30449675
J Biol Chem. 2019 Feb 8;294(6):2180-2190
pubmed: 30425096