Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure.
acute respiratory distress syndrome
acute respiratory failure
alveolar epithelial injury
body mass index
children
mechanical ventilation
obesity
pediatric
surfactant protein D
Journal
Pediatric pulmonology
ISSN: 1099-0496
Titre abrégé: Pediatr Pulmonol
Pays: United States
ID NLM: 8510590
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
02
06
2020
revised:
24
07
2020
accepted:
27
07
2020
pubmed:
30
7
2020
medline:
2
3
2021
entrez:
30
7
2020
Statut:
ppublish
Résumé
Alveolar epithelial injury is a key determinant of acute respiratory failure (ARF) severity. Plasma surfactant protein D (SP-D), a biomarker of alveolar epithelial injury, is lower in obese adults with ARF compared to their lean peers. We aimed to determine if children with ARF have similar variance in plasma SP-D associated with their weight status on admission. Plasma SP-D was measured on days 0, 1, or 2 in children (1-18 years) with ARF enrolled in the genetic variation and biomarkers in children with acute lung injury and RESTORE studies. Weight classification (underweight, normal, overweight, and obese) was based on body mass index or weight-for-height z-scores. Associations between weight group and SP-D on each day were tested. Inclusion criteria were met in 212 subjects, 24% were obese. There were no differences among weight groups in SP-D levels on days 0 and 1. However, on day 2, there was a statistically significant linear trend for lower SP-D levels as weight increased in both the univariate analysis (P = .02) and when adjusting for age, ethnicity, and diagnosis of pediatric acute respiratory distress syndrome (P = .05). Obesity was associated with lower plasma SP-D levels on day 2 of ARF. This finding may be explained by altered ARF pathogenesis in obese individuals or a reduced incidence of ventilator-induced lung injury.
Identifiants
pubmed: 32725941
doi: 10.1002/ppul.24990
pmc: PMC8087214
mid: NIHMS1644035
doi:
Substances chimiques
Biomarkers
0
Pulmonary Surfactant-Associated Protein D
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2730-2736Subventions
Organisme : NICHD NIH HHS
ID : R01 HD092471
Pays : United States
Organisme : NICHD NIH HHS
ID : HD092471
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL086622
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL086649
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL0114484
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL095410
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL140026
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL095410
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL114484
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL086649
Pays : United States
Organisme : NICHD NIH HHS
ID : K12HD047349
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD047349
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL140026
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL086622
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
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