Adenosine A

Adenosine A2 Receptor Antagonists / pharmacology Animals Brain-Computer Interfaces Calcium Signaling / drug effects Implantable Neurostimulators Learning / drug effects Mice Mice, Inbred C57BL Motor Cortex / drug effects Neurons / drug effects Photometry / instrumentation Purines / pharmacology Receptor, Adenosine A2A / metabolism Volition / drug effects
Adenosine A(2A) receptor Brain-machine interfaces Neuroprosthetic learning Population calcium signal Representation neuroplasticity Volitional control

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
01 11 2020
Historique:
received: 08 05 2020
revised: 12 07 2020
accepted: 20 07 2020
pubmed: 30 7 2020
medline: 13 8 2021
entrez: 30 7 2020
Statut: ppublish

Résumé

Volitional control is at the core of brain-machine interfaces (BMI) adaptation and neuroprosthetic-driven learning to restore motor function for disabled patients, but neuroplasticity changes and neuromodulation underlying volitional control of neuroprosthetic learning are largely unexplored. To better study volitional control at annotated neural population, we have developed an operant neuroprosthetic task with closed-loop feedback system by volitional conditioning of population calcium signal in the M1 cortex using fiber photometry recording. Importantly, volitional conditioning of the population calcium signal in M1 neurons did not improve within-session adaptation, but specifically enhanced across-session neuroprosthetic skill learning with reduced time-to-target and the time to complete 50 successful trials. With brain-behavior causality of the neuroprosthetic paradigm, we revealed that proficiency of neuroprosthetic learning by volitional conditioning of calcium signal was associated with the stable representational (plasticity) mapping in M1 neurons with the reduced calcium peak. Furthermore, pharmacological blockade of adenosine A

Identifiants

DOI: 10.1016/j.neuropharm.2020.108250 PMID: 32726599
pubmed: 32726599
pii: S0028-3908(20)30318-X
doi: 10.1016/j.neuropharm.2020.108250
pii:
doi:

Substances chimiques

Adenosine A2 Receptor Antagonists 0
Purines 0
Receptor, Adenosine A2A 0
istradefylline 2GZ0LIK7T4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108250

Informations de copyright

Copyright © 2020. Published by Elsevier Ltd.

Auteurs

Liping Zhang (L)

The Molecular Neuropharmacology Lab, School of Optometry and Ophthalmology, Wenzhou Medical University, China; The State Key Laboratory, School of Optometry and Ophthalmology, Wenzhou Medical University, China.

Yuling Zhou (Y)

The Molecular Neuropharmacology Lab, School of Optometry and Ophthalmology, Wenzhou Medical University, China; The State Key Laboratory, School of Optometry and Ophthalmology, Wenzhou Medical University, China.

Chengwei Liu (C)

The Molecular Neuropharmacology Lab, School of Optometry and Ophthalmology, Wenzhou Medical University, China; The State Key Laboratory, School of Optometry and Ophthalmology, Wenzhou Medical University, China.

Wu Zheng (W)

The Molecular Neuropharmacology Lab, School of Optometry and Ophthalmology, Wenzhou Medical University, China; The State Key Laboratory, School of Optometry and Ophthalmology, Wenzhou Medical University, China.

Zhimo Yao (Z)

The Molecular Neuropharmacology Lab, School of Optometry and Ophthalmology, Wenzhou Medical University, China; The State Key Laboratory, School of Optometry and Ophthalmology, Wenzhou Medical University, China.

Qin Wang (Q)

The Molecular Neuropharmacology Lab, School of Optometry and Ophthalmology, Wenzhou Medical University, China; The State Key Laboratory, School of Optometry and Ophthalmology, Wenzhou Medical University, China.

Yile Jin (Y)

Qiushi Academy of Advanced Studies and College of Biomedical Engineering and Instrumental Science, Zhejiang University, China.

Shaomin Zhang (S)

Qiushi Academy of Advanced Studies and College of Biomedical Engineering and Instrumental Science, Zhejiang University, China.

Weidong Chen (W)

Qiushi Academy of Advanced Studies and College of Biomedical Engineering and Instrumental Science, Zhejiang University, China.

Jiang-Fan Chen (JF)

The Molecular Neuropharmacology Lab, School of Optometry and Ophthalmology, Wenzhou Medical University, China; The State Key Laboratory, School of Optometry and Ophthalmology, Wenzhou Medical University, China. Electronic address: chenjf555@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents purinergiques › Antagonistes purinergiques › Antagonistes des récepteurs purinergiques P1 › Antagonistes des récepteurs A2 à l'adénosine › Adenosine A
questionsmedicales.fr › Eucaryotes › Animaux › Adenosine A
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures électriques › Interfaces cerveau-ordinateur › Adenosine A
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Adenosine A
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Électrodes implantées › Neurostimulateurs implantables › Adenosine A
questionsmedicales.fr › Phénomènes psychologiques › Psychologie appliquée › Apprentissage › Adenosine A
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Adenosine A
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Adenosine A
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Cortex sensorimoteur › Cortex moteur › Adenosine A
questionsmedicales.fr › Cellules › Neurones › Adenosine A
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Photométrie › Adenosine A
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Adenosine A
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P1 › Récepteurs A2 à l'adénosine › Récepteur A2A à l'adénosine › Adenosine A
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Volition › Adenosine A