Mastication Affects Transcriptomes of Mouse Microglia.
Brain tumor
DNA microarray
cognition
neuroimmunity
regulation of actin cytoskeleton
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
23
05
2020
revised:
16
06
2020
accepted:
17
06
2020
entrez:
31
7
2020
pubmed:
31
7
2020
medline:
11
8
2020
Statut:
ppublish
Résumé
We investigated whether mastication affects microglia, whose activity is thought to be associated with cognition and brain tumor progression. We kept mice by feeding either a hard or soft diet for 2, 4 or 8 months. After each period, we removed the whole brains and isolated microglia. The total RNA extracted from each brain's microglia was subjected to DNA microarray analysis. Many genes were found to be significantly differentially expressed between hard- and soft-diet-fed mice in each group of the same feeding period. The expression of several genes involved in the regulation of actin cytoskeleton was down-regulated in the soft-diet-fed mice. Mastication may affect microglia's roles in cognition as well as their neuroimmune activity through their activity of patrolling the brain.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
We investigated whether mastication affects microglia, whose activity is thought to be associated with cognition and brain tumor progression.
MATERIALS AND METHODS
METHODS
We kept mice by feeding either a hard or soft diet for 2, 4 or 8 months. After each period, we removed the whole brains and isolated microglia. The total RNA extracted from each brain's microglia was subjected to DNA microarray analysis.
RESULTS
RESULTS
Many genes were found to be significantly differentially expressed between hard- and soft-diet-fed mice in each group of the same feeding period. The expression of several genes involved in the regulation of actin cytoskeleton was down-regulated in the soft-diet-fed mice.
CONCLUSION
CONCLUSIONS
Mastication may affect microglia's roles in cognition as well as their neuroimmune activity through their activity of patrolling the brain.
Identifiants
pubmed: 32727798
pii: 40/8/4719
doi: 10.21873/anticanres.14473
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4719-4727Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.