InsP
P bodies
cellular homeostasis
inositol
signaling
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
11 08 2020
11 08 2020
Historique:
pubmed:
31
7
2020
medline:
21
10
2020
entrez:
31
7
2020
Statut:
ppublish
Résumé
Regulation of enzymatic 5' decapping of messenger RNA (mRNA), which normally commits transcripts to their destruction, has the capacity to dynamically reshape the transcriptome. For example, protection from 5' decapping promotes accumulation of mRNAs into processing (P) bodies-membraneless, biomolecular condensates. Such compartmentalization of mRNAs temporarily removes them from the translatable pool; these repressed transcripts are stabilized and stored until P-body dissolution permits transcript reentry into the cytosol. Here, we describe regulation of mRNA stability and P-body dynamics by the inositol pyrophosphate signaling molecule 5-InsP
Identifiants
pubmed: 32727897
pii: 1922284117
doi: 10.1073/pnas.1922284117
pmc: PMC7431097
doi:
Substances chimiques
Inositol Phosphates
0
RNA Caps
0
RNA, Messenger
0
1-diphosphoinositol pentakisphosphate
148077-18-3
Phosphotransferases (Phosphate Group Acceptor)
EC 2.7.4.-
PPIP5K1 protein, human
EC 2.7.4.21
PPIP5K2 protein, human
EC 2.7.4.24
Acid Anhydride Hydrolases
EC 3.6.-
diphosphoinositol polyphosphate phosphohydrolase
EC 3.6.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19245-19253Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM126488
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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