Optomechanical mass spectrometry.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
29 07 2020
29 07 2020
Historique:
received:
24
03
2020
accepted:
01
07
2020
entrez:
31
7
2020
pubmed:
31
7
2020
medline:
22
9
2020
Statut:
epublish
Résumé
Nanomechanical mass spectrometry has proven to be well suited for the analysis of high mass species such as viruses. Still, the use of one-dimensional devices such as vibrating beams forces a trade-off between analysis time and mass resolution. Complex readout schemes are also required to simultaneously monitor multiple resonance modes, which degrades resolution. These issues restrict nanomechanical MS to specific species. We demonstrate here single-particle mass spectrometry with nano-optomechanical resonators fabricated with a Very Large Scale Integration process. The unique motion sensitivity of optomechanics allows designs that are impervious to particle position, stiffness or shape, opening the way to the analysis of large aspect ratio biological objects of great significance such as viruses with a tail or fibrils. Compared to top-down beam resonators with electrical read-out and state-of-the-art mass resolution, we show a three-fold improvement in capture area with no resolution degradation, despite the use of a single resonance mode.
Identifiants
pubmed: 32728047
doi: 10.1038/s41467-020-17592-9
pii: 10.1038/s41467-020-17592-9
pmc: PMC7391691
doi:
Substances chimiques
Amyloid
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3781Références
Heberer, T. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol. Lett. 131, 5–17 (2002).
doi: 10.1016/S0378-4274(02)00041-3
Robinson, C. V., Sali, A. & Baumeister, W. The molecular sociology of the cell. Nature 450, 973–982 (2007).
doi: 10.1038/nature06523
Snijder, J., Rose, R. J., Veesler, D., Johnson, J. E. & Heck, A. J. R. Studying 18 MDa virus assemblies with native mass spectrometry. Angew. Chem. - Int. Ed. 52, 4020–4023 (2013).
doi: 10.1002/anie.201210197
Doussineau, T. et al. Mass determination of entire amyloid fibrils by using mass spectrometry. Angew. Chem. Int. Ed. 55, 2340–2344 (2016).
doi: 10.1002/anie.201508995
Keifer, D. Z., Motwani, T., Teschke, C. M. & Jarrold, M. F. Measurement of the accurate mass of a 50 MDa infectious virus. Rapid Commun. Mass Spectrom. 30, 1957–1962 (2016).
doi: 10.1002/rcm.7673
Chaste, J. et al. A nanomechanical mass sensor with yoctogram resolution. Nat. Nanotechnol. 7, 301–304 (2012).
doi: 10.1038/nnano.2012.42
Hanay, M. S. et al. Single-protein nanomechanical mass spectrometry in real time. Nat. Nanotechnol. 7, 602–608 (2012).
doi: 10.1038/nnano.2012.119
Sage, E. et al. Neutral particle mass spectrometry with nanomechanical systems. Nat. Commun. 6, 6482 (2015).
doi: 10.1038/ncomms7482
Sage, E. et al. Single-particle mass spectrometry with arrays of frequency-addressed nanomechanical resonators. Nat. Commun. 9, 3283 (2018).
doi: 10.1038/s41467-018-05783-4
Stassi, S. et al. Large-scale parallelization of nanomechanical mass spectrometry with weakly-coupled resonators. Nat. Commun. 10, 3647 (2019).
doi: 10.1038/s41467-019-11647-2
Dominguez-Medina, S. et al. Neutral mass spectrometry of virus capsids above 100 megadaltons with nanomechanical resonators. Science 362, 918–922 (2018).
doi: 10.1126/science.aat6457
Malvar, O. et al. Mass and stiffness spectrometry of nanoparticles and whole intact bacteria by multimode nanomechanical resonators. Nat. Commun. 7, 13452 (2016).
doi: 10.1038/ncomms13452
Sader, J. E., Hanay, M. S., Neumann, A. P. & Roukes, M. L. Mass spectrometry using nanomechanical systems: beyond the point-mass approximation. Nano Lett. 18, 1608–1614 (2018).
doi: 10.1021/acs.nanolett.7b04301
Favero, I. & Karrai, K. Optomechanics of deformable optical cavities. Nat. Photonics 3, 201–205 (2009).
doi: 10.1038/nphoton.2009.42
Aspelmeyer, M., Kippenberg, T. J. & Marquardt, F. Cavity optomechanics. Rev. Mod. Phys. 86, 1391 (2014).
Krause, A. G., Winger, M., Blasius, T. D., Lin, Q. & Painter, O. A high-resolution microchip optomechanical accelerometer. Nat. Photonics 6, 768–772 (2012).
doi: 10.1038/nphoton.2012.245
Dong, B., Cai, H., Tsai, J. M., Kwong, D. L. & Liu, A. Q. An on-chip opto-mechanical accelerometer. In 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS) 641–644 (2013).
Venkatasubramanian, A. et al. Nano-optomechanical systems for gas chromatography. Nano Lett. 16, 6975–6981 (2016).
doi: 10.1021/acs.nanolett.6b03066
Yu, W., Jiang, W. C., Lin, Q. & Lu, T. Cavity optomechanical spring sensing of single molecules. Nat. Commun. 7, 1–9 (2016).
Etienne Allain, P. et al. Optomechanical resonating probe for very high frequency sensing of atomic forces. Nanoscale 12, 2939–2935 (2020).
Liu, F., Alaie, S., Leseman, Z. C. & Hossein-Zadeh, M. Sub-pg mass sensing and measurement with an optomechanical oscillator. Opt. Express 21, 19555 (2013).
doi: 10.1364/OE.21.019555
Gil-Santos, E. et al. Optomechanical detection of vibration modes of a single bacterium. Nat. Nanotechnol. 15, 467–474 (2020).
Sansa, M. et al. Frequency fluctuations in silicon nanoresonators. Nat. Nanotechnol. 11, 552–559 (2016).
doi: 10.1038/nnano.2016.19
Rahafrooz, A. & Pourkamali, S. Fabrication and characterization of thermally actuated micromechanical resonators for airborne particle mass sensing: I. Resonator design and modeling. J. Micromech. Microeng. 20, 125018 (2010).
doi: 10.1088/0960-1317/20/12/125018
Perelló-Roig, R., Verd, J., Barceló, J., Bota, S. & Segura, J. A 0.35-μm CMOS-MEMS oscillator for high-resolution distributed mass detection. Micromachines 9, 484 (2018).
doi: 10.3390/mi9100484
Ding, L. et al. Gallium Arsenide Disk Optomechanical Resonators. in Handbook of Optical Microcavities 526 (Pan Stanford, 2014).
Schwab, L. et al. Comprehensive optical losses investigation of VLSI Silicon optomechanical ring resonator sensors. In 2018 IEEE International Electron Devices Meeting (IEDM) San Francisco, CA, pp. 4.7.1–4.7.4 (2018).
Gorodetksy, M. L., Schliesser, A., Anetsberger, G., Deleglise, S. & Kippenberg, T. J. Determination of the vacuum optomechanical coupling rate using frequency noise calibration. Opt. Express 18, 23236–23246 (2010).
doi: 10.1364/OE.18.023236
Bernabé, S. et al. Chip-to-chip optical interconnections between stacked self-aligned SOI photonic chips. Opt. Express 20, 7886–7894 (2012).
doi: 10.1364/OE.20.007886
Allan, D. W. Time and frequency (time-domain) characterization, estimation, and prediction of precision clocks and oscillators. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 34, 647–654 (1987).
doi: 10.1109/T-UFFC.1987.26997
Yuksel, M. et al. Nonlinear nanomechanical mass spectrometry at the single-nanoparticle level. Nano Lett. 19, 3583–3589 (2019).
doi: 10.1021/acs.nanolett.9b00546
MacDonald, A. J. R. et al. Optical microscope and tapered fiber coupling apparatus for a dilution refrigerator. Rev. Sci. Instrum. 86, 013107 (2015).
doi: 10.1063/1.4905682
Gil Santos, E. et al. Light-mediated cascaded locking of multiple nano-optomechanical oscillators. Phys. Rev. Lett. 118, 063605 (2017).
doi: 10.1103/PhysRevLett.118.063605
Morel, R., Brenac, A., Bayle-Guillemaud, P., Portemont, C. & Rizza, F. L. Growth and properties of cobalt clusters made by sputtering gas-aggregation. Eur. Phys. J. 24, 287–290 (2003).
Sauer, V. T. K., Diao, Z., Freeman, M. R. & Hiebert, W. K. Wavelength-division multiplexing of nano-optomechanical doubly clamped beam systems. Opt. Lett. 40, 1948 (2015).
doi: 10.1364/OL.40.001948
Ding, L. et al. High frequency GaAs nano-optomechanical disk resonator. Phys. Rev. Lett. 105, 263903 (2010).
doi: 10.1103/PhysRevLett.105.263903