Single-cell approaches to investigate B cells and antibodies in autoimmune neurological disorders.
Affinity
Autoimmunity
B cell tolerance
B cells
Central nervous system
Epitope
Monoclonal
Neurological disorders
Pathogenicity
Recombinant antibodies
Sequencing
Single cell
Journal
Cellular & molecular immunology
ISSN: 2042-0226
Titre abrégé: Cell Mol Immunol
Pays: China
ID NLM: 101242872
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
10
06
2020
accepted:
07
07
2020
pubmed:
31
7
2020
medline:
28
12
2021
entrez:
31
7
2020
Statut:
ppublish
Résumé
Autoimmune neurological disorders, including neuromyelitis optica spectrum disorder, anti-N-methyl-D-aspartate receptor encephalitis, anti-MOG antibody-associated disorders, and myasthenia gravis, are clearly defined by the presence of autoantibodies against neurological antigens. Although these autoantibodies have been heavily studied for their biological activities, given the heterogeneity of polyclonal patient samples, the characteristics of a single antibody cannot be definitively assigned. This review details the findings of polyclonal serum and CSF studies and then explores the advances made by single-cell technologies to the field of antibody-mediated neurological disorders. High-resolution single-cell methods have revealed abnormalities in the tolerance mechanisms of several disorders and provided further insight into the B cells responsible for autoantibody production. Ultimately, several factors, including epitope specificity and binding affinity, finely regulate the pathogenic potential of an autoantibody, and a deeper appreciation of these factors may progress the development of targeted immunotherapies for patients.
Identifiants
pubmed: 32728203
doi: 10.1038/s41423-020-0510-z
pii: 10.1038/s41423-020-0510-z
pmc: PMC8027387
doi:
Substances chimiques
Autoantibodies
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
294-306Références
J Clin Invest. 2015 Nov 2;125(11):4160-70
pubmed: 26436649
Mol Immunol. 2011 Jun;48(11):1328-31
pubmed: 21216012
Curr Rheumatol Rep. 2018 Sep 6;20(10):65
pubmed: 30191417
Front Immunol. 2013 Jul 29;4:217
pubmed: 23908655
Ann Neurol. 2018 Mar;83(3):553-561
pubmed: 29406578
Neurology. 2014 Apr 15;82(15):1302-6
pubmed: 24634453
Lancet Neurol. 2013 Feb;12(2):157-65
pubmed: 23290630
N Engl J Med. 2019 Aug 15;381(7):614-625
pubmed: 31050279
Nat Med. 2001 Nov;7(11):1189-93
pubmed: 11689882
Autoimmun Rev. 2008 Feb;7(4):317-21
pubmed: 18295737
Ann N Y Acad Sci. 2015 Sep;1351:22-38
pubmed: 26083906
J Neuroimmunol. 2011 May;234(1-2):124-30
pubmed: 21316112
Mol Cell Neurosci. 2009 Aug;41(4):383-96
pubmed: 19394426
Ciba Found Symp. 1982;(90):197-224
pubmed: 6923808
JAMA Neurol. 2018 Apr 1;75(4):478-487
pubmed: 29305608
Neuropharmacology. 2020 Jan 1;162:107827
pubmed: 31654702
Ther Adv Neurol Disord. 2011 Sep;4(5):259-66
pubmed: 22010039
Cell. 2015 May 21;161(5):1202-1214
pubmed: 26000488
Brief Funct Genomics. 2018 Jul 1;17(4):233-239
pubmed: 29126257
Mod Rheumatol. 2013 Jul;23(4):827-31
pubmed: 22782533
Nat Rev Neurol. 2017 May;13(5):290-301
pubmed: 28418022
Nat Med. 2007 Feb;13(2):211-7
pubmed: 17237795
Genomics Proteomics Bioinformatics. 2021 Apr;19(2):253-266
pubmed: 33662621
Ann Clin Transl Neurol. 2017 Oct 03;4(11):768-783
pubmed: 29159189
Ann Neurol. 2009 Nov;66(5):617-29
pubmed: 19938104
Nat Biotechnol. 2010 Nov;28(11):1203-7
pubmed: 20953198
Neurol Neuroimmunol Neuroinflamm. 2019 Oct 14;6(6):625
pubmed: 31611268
Brain. 2016 Oct;139(Pt 10):2641-2652
pubmed: 27543972
Autoimmun Rev. 2013 Jul;12(9):904-11
pubmed: 23537510
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20783-8
pubmed: 24297891
Brain. 2015 Jan;138(Pt 1):94-109
pubmed: 25392198
Arthritis Rheumatol. 2017 Apr;69(4):687-699
pubmed: 28085999
J Clin Invest. 2019 Apr 8;129(5):2000-2013
pubmed: 30958797
JCI Insight. 2020 Jul 23;5(14):
pubmed: 32573488
PLoS One. 2009 Dec 29;4(12):e8474
pubmed: 20041189
JAMA Neurol. 2015 Jul;72(7):756-63
pubmed: 25985228
Brain. 2010 Feb;133(Pt 2):349-61
pubmed: 20047900
J Exp Med. 2005 Mar 7;201(5):703-11
pubmed: 15738055
Brain. 2020 Jun 1;143(6):1731-1745
pubmed: 32437528
Sci Rep. 2015 Sep 10;5:13928
pubmed: 26355076
JCI Insight. 2017 Sep 7;2(17):
pubmed: 28878127
Ann Neurol. 2009 Dec;66(6):833-42
pubmed: 20033986
Cell. 1978 Sep;15(1):1-14
pubmed: 100225
Brain. 2007 May;130(Pt 5):1235-43
pubmed: 17449477
PLoS One. 2013 Dec 10;8(12):e83036
pubmed: 24340077
J Neurol. 2021 May;268(5):1689-1707
pubmed: 31655889
Lancet. 2001 Jun 30;357(9274):2122-8
pubmed: 11445126
JCI Insight. 2019 Jun 20;4(12):
pubmed: 31217355
N Engl J Med. 2016 Dec 29;375(26):2570-2581
pubmed: 28029925
Arch Neurol. 2009 Sep;66(9):1164-7
pubmed: 19752309
J Clin Invest. 2016 Jan;126(1):282-7
pubmed: 26642366
Acta Neuropathol Commun. 2019 Sep 3;7(1):145
pubmed: 31481127
Ann Neurol. 2019 May;85(5):771-776
pubmed: 30843274
J Clin Invest. 2013 Jun;123(6):2737-41
pubmed: 23676463
J Neurol Neurosurg Psychiatry. 2019 Apr;90(4):486-487
pubmed: 29929977
Ann Clin Transl Neurol. 2016 Apr 27;3(6):443-54
pubmed: 27547772
Science. 2003 Sep 5;301(5638):1374-7
pubmed: 12920303
Cell Biosci. 2019 Jun 26;9:53
pubmed: 31391919
Science. 2007 Sep 14;317(5844):1554-7
pubmed: 17872445
J Biol Chem. 2015 May 8;290(19):12123-34
pubmed: 25792738
Brain. 2012 May;135(Pt 5):1606-21
pubmed: 22544902
Front Immunol. 2019 Feb 27;10:318
pubmed: 30873171
Curr Opin Immunol. 2008 Dec;20(6):632-8
pubmed: 18848883
Neurol Neuroimmunol Neuroinflamm. 2020 Feb 5;7(2):
pubmed: 32024795
Front Immunol. 2018 Mar 12;9:410
pubmed: 29593711
Ann Neurol. 2007 Jan;61(1):25-36
pubmed: 17262855
Nat Rev Neurol. 2019 Feb;15(2):89-102
pubmed: 30559466
J Immunol. 2013 Oct 1;191(7):3594-604
pubmed: 24014878
FASEB J. 2012 May;26(5):2197-208
pubmed: 22319008
Ann Neurol. 2020 Feb;87(2):256-266
pubmed: 31725931
Ann Clin Transl Neurol. 2017 May 09;4(6):369-380
pubmed: 28589164
J Neurol. 2018 Nov;265(11):2625-2632
pubmed: 30187160
Neurology. 2010 Nov 9;75(19):1735-9
pubmed: 21060097
J Immunol Methods. 2008 Jan 1;329(1-2):112-24
pubmed: 17996249
Neurol Neuroimmunol Neuroinflamm. 2019 Feb 21;6(3):e547
pubmed: 30882021
Lancet. 2004 Dec 11-17;364(9451):2106-12
pubmed: 15589308
Arch Neurol. 2009 Sep;66(9):1128-33
pubmed: 19752302
Adv Immunol. 2007;95:83-110
pubmed: 17869611
Epilepsia. 2013 Sep;54 Suppl 6:78-80
pubmed: 24001081
Lancet. 2019 Oct 12;394(10206):1352-1363
pubmed: 31495497
JAMA Neurol. 2013 Mar 1;70(3):394-7
pubmed: 23358868
JAMA Neurol. 2016 Nov 01;73(11):1342-1348
pubmed: 27668357
J Neurol. 2014 Jan;261(1):1-16
pubmed: 24272588
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3628-32
pubmed: 824647
Neuroscience. 2020 Jul 15;439:48-61
pubmed: 32194225
Oncol Lett. 2017 Nov;14(5):5671-5680
pubmed: 29113194
Ann Neurol. 2014 Jul;76(1):108-19
pubmed: 24916964
J Neurosci. 2010 Apr 28;30(17):5866-75
pubmed: 20427647
Autoimmun Rev. 2016 Apr;15(4):307-24
pubmed: 26708342
J Clin Neurosci. 2014 May;21(5):722-30
pubmed: 24246947
Brain. 2015 Nov;138(Pt 11):3159-67
pubmed: 26373601
BMJ Case Rep. 2014 Mar 26;2014:
pubmed: 24671322
Curr Opin Neurol. 2019 Jun;32(3):385-394
pubmed: 30893099
Clin Exp Immunol. 1984 Oct;58(1):97-106
pubmed: 6236921
J Neurosci. 2012 Aug 8;32(32):11082-94
pubmed: 22875940
Lancet Neurol. 2020 May;19(5):402-412
pubmed: 32333898
Brain. 2018 Apr 1;141(4):1063-1074
pubmed: 29447335
J Exp Med. 2005 Aug 15;202(4):473-7
pubmed: 16087714
Ann Neurol. 2018 Aug;84(2):315-328
pubmed: 30014603
Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19854-9
pubmed: 17170137
Neurology. 2011 Aug 16;77(7):659-66
pubmed: 21813788
J Neuroinflammation. 2015 Jan 28;12:19
pubmed: 25626447
JAMA Neurol. 2013 Mar 1;70(3):390-3
pubmed: 23599943
Brain Sci. 2017 Jun 22;7(7):
pubmed: 28640199
Brain. 2018 Feb 1;141(2):348-356
pubmed: 29272336
Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3701-6
pubmed: 21321193
J Clin Invest. 2015 Jun;125(6):2203-10
pubmed: 25938781
Brain. 2012 Apr;135(Pt 4):1081-101
pubmed: 22396395
Neurology. 2012 Jan 17;78(3):189-93
pubmed: 22218276
Lancet Neurol. 2008 Dec;7(12):1091-8
pubmed: 18851928
Nat Rev Neurosci. 2019 Dec;20(12):728-745
pubmed: 31712781
Neurology. 2005 Apr 12;64(7):1270-2
pubmed: 15824362
Neurology. 1976 Nov;26(11):1054-9
pubmed: 988512
Autoimmunity. 2015;48(6):362-8
pubmed: 25915571
PLoS One. 2013 Nov 07;8(11):e80695
pubmed: 24244707
Ann N Y Acad Sci. 2011 Dec;1246:1-10
pubmed: 22236425
Nat Rev Rheumatol. 2019 May;15(5):303-315
pubmed: 30967621
J Neuroinflammation. 2019 Jul 2;16(1):134
pubmed: 31266527
Front Immunol. 2017 Jun 06;8:646
pubmed: 28634480
Cell. 2015 May 21;161(5):1187-1201
pubmed: 26000487
Clin Med (Lond). 2019 Mar;19(2):169-176
pubmed: 30872305
Brain. 2019 Jun 1;142(6):1598-1615
pubmed: 31056665
J Neurol Neurosurg Psychiatry. 2018 Feb;89(2):127-137
pubmed: 29142145
J Exp Med. 2005 May 16;201(10):1659-67
pubmed: 15897279
J Immunol. 2009 Sep 15;183(6):4067-76
pubmed: 19687098
Lancet Neurol. 2019 Nov;18(11):1045-1057
pubmed: 31326280
Semin Immunopathol. 2015 Mar;37(2):187-97
pubmed: 25404121
Ann Neurol. 2018 Sep;84(3):473-480
pubmed: 30076629
Ann Neurol. 2012 Mar;71(3):314-22
pubmed: 22271321
J Neuroimmunol. 2013 Dec 15;265(1-2):128-30
pubmed: 24183642