The role of 44-methylgambierone in ciguatera fish poisoning: Acute toxicity, production by marine microalgae and its potential as a biomarker for Gambierdiscus spp.

Animals Biomarkers Chromatography, Liquid Ciguatera Poisoning Dinoflagellida Mice Microalgae
Benthic dinoflagellate Ciguatoxin Liquid chromatography-tandem mass spectrometry Maitotoxin-3 Quantitative nuclear magnetic resonance spectroscopy

Journal

Harmful algae
ISSN: 1878-1470
Titre abrégé: Harmful Algae
Pays: Netherlands
ID NLM: 101128968

Informations de publication

Date de publication:
07 2020
Historique:
received: 21 04 2020
revised: 01 06 2020
accepted: 07 06 2020
entrez: 1 8 2020
pubmed: 1 8 2020
medline: 18 3 2021
Statut: ppublish

Résumé

Ciguatera fish poisoning (CFP) is prevalent around the tropical and sub-tropical latitudes of the world and impacts many Pacific island communities intrinsically linked to the reef system for sustenance and trade. While the genus Gambierdiscus has been linked with CFP, it is commonly found on tropical reef systems in microalgal assemblages with other genera of toxin-producing, epiphytic and/or benthic dinoflagellates - Amphidinium, Coolia, Fukuyoa, Ostreopsis and Prorocentrum. Identifying a biomarker compound that can be used for the early detection of Gambierdiscus blooms, specifically in a mixed microalgal community, is paramount in enabling the development of management and mitigation strategies. Following on from the recent structural elucidation of 44-methylgambierone, its potential to contribute to CFP intoxication events and applicability as a biomarker compound for Gambierdiscus spp. was investigated. The acute toxicity of this secondary metabolite was determined by intraperitoneal injection using mice, which showed it to be of low toxicity, with an LD

Identifiants

DOI: 10.1016/j.hal.2020.101853 PMID: 32732047
pubmed: 32732047
pii: S1568-9883(20)30132-3
doi: 10.1016/j.hal.2020.101853
pii:
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101853

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors have declared no conflict of interest.

Auteurs

J Sam Murray (JS)

Cawthron Institute, Private Bag 2, Nelson 7042, New Zealand; New Zealand Food Safety Science and Research Centre, Massey University, Private Bag 11-222, Palmerston North 4442, New Zealand; School of Science, University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand. Electronic address: sam.murray@cawthron.org.nz.

Tomohiro Nishimura (T)

Cawthron Institute, Private Bag 2, Nelson 7042, New Zealand.

Sarah C Finch (SC)

AgResearch, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand.

Lesley L Rhodes (LL)

Cawthron Institute, Private Bag 2, Nelson 7042, New Zealand.

Jonathan Puddick (J)

Cawthron Institute, Private Bag 2, Nelson 7042, New Zealand.

D Tim Harwood (DT)

Cawthron Institute, Private Bag 2, Nelson 7042, New Zealand; New Zealand Food Safety Science and Research Centre, Massey University, Private Bag 11-222, Palmerston North 4442, New Zealand.

Michaela E Larsson (ME)

Climate Change Cluster, University of Technology Sydney, P.O. Box 123 Broadway, Sydney, NSW 2007, Australia.

Martina A Doblin (MA)

Climate Change Cluster, University of Technology Sydney, P.O. Box 123 Broadway, Sydney, NSW 2007, Australia.

Priscilla Leung (P)

State Key Laboratory of Marine Pollution, City University of Hong Kong, Hong Kong, China; Research Centre for the Oceans and Human Health, City University of Hong Kong Shenzhen Research Institute, Shenzhen, China.

Meng Yan (M)

State Key Laboratory of Marine Pollution, City University of Hong Kong, Hong Kong, China; Research Centre for the Oceans and Human Health, City University of Hong Kong Shenzhen Research Institute, Shenzhen, China.

Frode Rise (F)

Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, NO-0315 Oslo, Norway.

Alistair L Wilkins (AL)

Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, NO-0315 Oslo, Norway.

Michèle R Prinsep (MR)

School of Science, University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The role of 44-methylgambierone in ciguatera...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › The role of 44-methylgambierone in ciguatera...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › The role of 44-methylgambierone in ciguatera...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Maladies d'origine alimentaire › Ciguatera › The role of 44-methylgambierone in ciguatera...
questionsmedicales.fr › Eucaryotes › Alveolata › Dinoflagellida › The role of 44-methylgambierone in ciguatera...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The role of 44-methylgambierone in ciguatera...
questionsmedicales.fr › Stades d'organismes › Plancton › Phytoplancton › Microalgues › The role of 44-methylgambierone in ciguatera...